Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, ul. Chalubinskiego 1, 50-368 Wroclaw, Poland.
Department of Dermatology and Allergology, Ludwig-Maximilian University, Thalkirchner Straße 48, 80539 Munich, Germany.
J Immunol Res. 2014;2014:628289. doi: 10.1155/2014/628289. Epub 2014 May 8.
The pathognesis of psoriasis still remains not fully elucidated. Recent advances favor the idea that interactions between innate and adaptive immune response drive inflammatory process in this disease. Innate antimicrobial peptides and proteins (AMPs) are diverse group of small molecules that provide the first line of defense against invading pathogens. In recent years, the novel functions of AMPs have been identified. There are three subclasses among AMPs that have gained the special interest as a potentially important player in the pathogenesis of psoriasis: cathelicidin, S100 proteins, and defensins. These AMPs have been shown to modulate and trigger host immune response in psoriasis acting as interplayer between innate and adaptive immune mechanisms. Overexpressed in psoriatic lesions, they prime immune cells for enhanced production of proinflammatory mediators and act as chemoattractant for leukocytes. Therefore, the novel term describing AMPs alarmins has been suggested. As multifunctional player in pathogenesis of psoriasis, AMPs may constitute potential target for therapeutic interventions. However, further investigations are required to establish the methods of downregulation of the aberrant proinflammatory functions of AMPs without increasing the risk of infections.
银屑病的发病机制仍不完全清楚。最近的研究进展支持这样一种观点，即先天免疫和适应性免疫反应之间的相互作用驱动了这种疾病的炎症过程。先天抗菌肽和蛋白质（AMPs）是小分子的多样化群体，为抵御入侵病原体提供了第一道防线。近年来，已经确定了 AMPs 的新功能。AMP 有三个亚类，它们作为银屑病发病机制中潜在的重要参与者而受到特别关注：抗菌肽、S100 蛋白和防御素。这些 AMP 已被证明在银屑病中调节和触发宿主免疫反应，作为先天和适应性免疫机制之间的介体。在银屑病皮损中过度表达，它们为免疫细胞增强产生促炎介质做好准备，并作为白细胞趋化因子。因此，提出了一个描述 AMPs 警报素的新术语。作为银屑病发病机制中的多功能参与者，AMPs 可能成为治疗干预的潜在靶点。然而，需要进一步的研究来确定下调 AMPs 异常促炎功能的方法，而不增加感染的风险。
