Zhang X, Chatwin C, Barber D C
Department of Engineering, University of Sussex, Brighton BN1 9QT, UK.
Physiol Meas. 2015 Jun;36(6):1311-35. doi: 10.1088/0967-3334/36/6/1311. Epub 2015 May 26.
A feasibility study of an electrical impedance mammography (EIM) system with a rotary planar electrode array, named RPEIM, is presented. The RPEIM system is an evolution of the Sussex MK4 system, which is a prototype instrument for breast cancer detection. Comparing it with the other planar electrode EIM systems, the rotation feature enables a dramatic increase in the number of independent measurements. To assist impedance evaluation exploiting electrode array rotation, a synchronous mesh method is proposed. Using the synchronous mesh method, the RPEIM system is shown to have superior performance in image accuracy, spatial resolution and noise tolerance over the MK4 system. To validate the study, we report simulations based on a close-to-realistic 3D digital breast phantom, which comprises of: skin, nipple, ducts, acinus, fat and tumor. A digital breast phantom of a real patient is constructed, whose tumor was detected using the MK4 system. The reconstructed conductivity image of the breast phantom indicates that the breast phantom is a close replica of the patient's real breast as assessed by the MK4 system in a clinical trial. A comparison between the RPEIM system and the MK4 system is made based on this phantom to assess the advantages of the RPEIM system.
本文介绍了一种具有旋转平面电极阵列的电阻抗乳腺成像(EIM)系统——旋转平面电极电阻抗乳腺成像(RPEIM)的可行性研究。RPEIM系统是苏塞克斯MK4系统的升级版,MK4系统是一种用于乳腺癌检测的原型仪器。与其他平面电极EIM系统相比,旋转特性使得独立测量的数量大幅增加。为了辅助利用电极阵列旋转进行阻抗评估,提出了一种同步网格方法。使用同步网格方法,RPEIM系统在图像准确性、空间分辨率和噪声耐受性方面表现出优于MK4系统的性能。为了验证该研究,我们报告了基于接近真实的三维数字乳腺模型的模拟,该模型包括:皮肤、乳头、导管、腺泡、脂肪和肿瘤。构建了一名真实患者的数字乳腺模型,其肿瘤在MK4系统检测下被发现。乳腺模型的重建电导率图像表明,在一项临床试验中,通过MK4系统评估,该乳腺模型与患者的真实乳房非常相似。基于该模型对RPEIM系统和MK4系统进行了比较,以评估RPEIM系统的优势。