Heine Martin, Wens Inez, Langeskov-Christensen Martin, Verschuren Olaf, Eijnde Bert O, Kwakkel Gert, Dalgas Ulrik
Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Utrecht, The Netherlands
Rehabilitation Research Center (REVAL), Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium.
Mult Scler. 2016 Feb;22(2):231-8. doi: 10.1177/1352458515581437. Epub 2015 May 26.
In persons with MS (pwMS), a lower cardiopulmonary fitness has been associated with a higher risk for secondary disorders, decreased functional capacity, symptom worsening and reduced health-related quality of life.
To investigate the association between disease severity and cardiopulmonary fitness.
Data from cardiopulmonary exercise tests, previously conducted in three different countries, were pooled. The association between disease severity (Expanded Disability Status Scale (EDSS)) and cardiopulmonary fitness (peak oxygen uptake (VO2peak)) was adjusted for age, sex and the country of origin.
The combined sample comprised 116 ambulant pwMS having a mean (± SD) EDSS score of 2.7 ± 1.3. There was a significant correlation (r = -0.418, p < .01) between VO2peak and EDSS. A multiple regression model (R(2) = 0.520, p < .01) was constructed to describe VO2peak (mL∙kg(-1)∙min(-1)); VO2peak = 36.622 - 5.433 (Sex (1=men)) - 0.124 (Age) - 2.082 (EDSS) + 2.737 (Belgium) + 8.674 (Denmark).
There was a significant association between disease severity and cardiopulmonary fitness. The close relation between cardiopulmonary fitness and chronic conditions associated with physical inactivity, suggest a progressive increase in risk of secondary health conditions in pwMS.
在多发性硬化症患者（pwMS）中，较低的心肺适能与继发疾病风险较高、功能能力下降、症状恶化及健康相关生活质量降低有关。
研究疾病严重程度与心肺适能之间的关联。
汇总先前在三个不同国家进行的心肺运动试验数据。针对年龄、性别和原籍国对疾病严重程度（扩展残疾状态量表（EDSS））与心肺适能（峰值摄氧量（VO2peak））之间的关联进行了校正。
合并样本包括116名能独立行走的pwMS患者，其平均（±标准差）EDSS评分为2.7±1.3。VO2peak与EDSS之间存在显著相关性（r = -0.418，p <.01）。构建了一个多元回归模型（R(2) = 0.520，p <.01）来描述VO2peak（mL∙kg(-1)∙min(-1)）；VO2peak = 36.622 - 5.433（性别（1 =男性）） - 0.124（年龄） - 2.082（EDSS） + 2.737（比利时） + 8.674（丹麦）。
疾病严重程度与心肺适能之间存在显著关联。心肺适能与因身体活动不足相关的慢性疾病之间的密切关系表明，pwMS患者继发健康问题的风险逐渐增加。
