Ardissone P, Valtorta M, Gallina M R, Silvestro L
Minerva Pediatr. 1989 Jun;41(6):301-4.
The serum concentration of protein C reactive (PCR) in preterm and term children was assessed on the first, fifth, eighth and fifteenth day of life. The data obtained show that in all cases characterised by PCR values higher than 10 mg/l on the first day of life a serious infectious pathology was present which required antibiotic treatment, monitored by subsequent PCR samplings. In all cases in which PCR was negative on the first day of life and in later samples, none had presented infectious pathologies. Analysis of the results showed that so-called borderline values (greater than 2 mg/l less than 10 mg/l) were present in some newborns at risk for the development of infectious pathologies. These children were subjected to antibiotic therapy as prophylaxis and in subsequent samples PCR became totally negative.
在出生后的第一天、第五天、第八天和第十五天，对早产和足月儿童的C反应蛋白（PCR）血清浓度进行了评估。获得的数据表明，在所有出生第一天PCR值高于10mg/l的病例中，均存在严重的感染性病理情况，需要进行抗生素治疗，并通过后续的PCR采样进行监测。在所有出生第一天及后续样本中PCR呈阴性的病例中，均未出现感染性病理情况。结果分析表明，一些有感染性病理发展风险的新生儿存在所谓的临界值（大于2mg/l小于10mg/l）。这些儿童接受了抗生素预防治疗，在后续样本中PCR完全转为阴性。
