Bisset G S
Department of Radiology, University of Cincinnati College of Medicine, Ohio.
Pediatr Radiol. 1989;20(1-2):61-6. doi: 10.1007/BF02010636.
Development of a practical oral contrast agent for magnetic resonance imaging is necessary to improve differentiation of bowel from adjacent structures. In order to find a readily available, inexpensive, non-toxic, palatable solution for use in the pediatric population, several formulas, milk products and a common oral sedative were evaluated in vitro. T1, T2 and signal intensity measurements were performed on a 1.5 T system. Similac with standard iron proved to be a useful high signal intensity agent on multiple pulse sequences. Early in vivo experience in four normal volunteers indicates that this agent provides excellent delineation of the stomach and duodenum from contiguous viscera. Distal small bowel visualization is less predictable. Further clinical trials should confirm the utility of this solution, which contains a combination of iron salts and paramagnetic metallic ions.
开发一种用于磁共振成像的实用口服造影剂对于改善肠道与相邻结构的区分是必要的。为了找到一种易于获得、价格低廉、无毒且适合儿科人群口味的溶液，对几种配方、奶制品和一种常见的口服镇静剂进行了体外评估。在1.5T系统上进行了T1、T2和信号强度测量。含标准铁的Similac奶粉在多个脉冲序列上被证明是一种有用的高信号强度造影剂。四名正常志愿者的早期体内实验表明，这种造影剂能很好地勾勒出胃和十二指肠与相邻内脏的轮廓。小肠远端的显影较难预测。进一步的临床试验应能证实这种含有铁盐和顺磁性金属离子组合的溶液的效用。
