Cory D A, Schwartzentruber D J, Mock B H
Magn Reson Imaging. 1987;5(1):65-70. doi: 10.1016/0730-725x(87)90485-1.
Solutions of manganese chloride were force-fed to Sprague-Dawley rats. Magnetic resonance (MR) imaging was performed on (a) syringes containing different concentrations of manganese chloride, (b) rats after force feeding and (c) livers excised after sacrifice of the force-fed rats. Imaging was done with a 0.15-T resistive magnet. Multiple pulse sequences were used and T1 values were calculated. The signal intensity and T1 value obtained from a solution depended on the manganese concentration and the pulse sequence employed. At higher concentrations, no signal was produced due to extreme T2 shortening. Absorbed manganese affected the signal intensities and T1 values of the rats' livers. By appropriate selection of manganese concentration and pulse sequence, ingested manganese can serve as a combined gastrointestinal and hepatic MR contrast agent.
将氯化锰溶液强制喂给斯普拉格-道利大鼠。对以下对象进行磁共振（MR）成像：（a）含有不同浓度氯化锰的注射器，（b）强制喂食后的大鼠，以及（c）强制喂食的大鼠处死后切除的肝脏。使用0.15-T电阻磁体进行成像。使用了多个脉冲序列并计算了T1值。从溶液中获得的信号强度和T1值取决于锰浓度和所采用的脉冲序列。在较高浓度下，由于T2极度缩短而不产生信号。吸收的锰影响大鼠肝脏的信号强度和T1值。通过适当选择锰浓度和脉冲序列，摄入的锰可作为胃肠道和肝脏联合MR造影剂。
