Hoek-van den Hil Elise F, van Schothorst Evert M, van der Stelt Inge, Swarts Hans J M, van Vliet Marjanne, Amolo Tom, Vervoort Jacques J M, Venema Dini, Hollman Peter C H, Rietjens Ivonne M C M, Keijer Jaap
Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands.
Genes Nutr. 2015 Jul;10(4):469. doi: 10.1007/s12263-015-0469-z. Epub 2015 May 29.
Dietary flavonoid intake is associated with reduced risk of cardiovascular diseases, possibly by affecting metabolic health. The relative potency of different flavonoids in causing beneficial effects on energy and lipid metabolism has not been investigated. Effects of quercetin, hesperetin, epicatechin, apigenin and anthocyanins in mice fed a high-fat diet (HF) for 12 weeks were compared, relative to normal-fat diet. HF-induced body weight gain was significantly lowered by all flavonoids (17-29 %), but most by quercetin. Quercetin significantly lowered HF-induced hepatic lipid accumulation (71 %). Mesenteric adipose tissue weight and serum leptin levels were significantly lowered by quercetin, hesperetin and anthocyanins. Adipocyte cell size and adipose tissue inflammation were not affected. The effect on body weight and composition could not be explained by individual significant effects on energy intake, energy expenditure or activity. Lipid metabolism was not changed as measured by indirect calorimetry or expression of known lipid metabolic genes in liver and white adipose tissue. Hepatic expression of Cyp2b9 was strongly downregulated by all flavonoids. In conclusion, all flavonoids lowered parameters of HF-induced adiposity, with quercetin being most effective.
膳食类黄酮的摄入与心血管疾病风险降低相关，可能是通过影响代谢健康实现的。不同类黄酮对能量和脂质代谢产生有益影响的相对效力尚未得到研究。将槲皮素、橙皮素、表儿茶素、芹菜素和花青素对喂食高脂饮食（HF）12周的小鼠的影响与正常脂肪饮食的小鼠进行了比较。所有类黄酮均显著降低了HF诱导的体重增加（17%-29%），但槲皮素的降低幅度最大。槲皮素显著降低了HF诱导的肝脏脂质积累（71%）。槲皮素、橙皮素和花青素显著降低了肠系膜脂肪组织重量和血清瘦素水平。脂肪细胞大小和脂肪组织炎症未受影响。对体重和组成的影响无法通过对能量摄入、能量消耗或活动的个体显著影响来解释。通过间接量热法或肝脏和白色脂肪组织中已知脂质代谢基因的表达来衡量，脂质代谢没有变化。所有类黄酮均强烈下调了肝脏中Cyp2b9的表达。总之，所有类黄酮均降低了HF诱导的肥胖参数，其中槲皮素最为有效。
