Kravchenia N A, Gorenshteĭn B I, Dezhurova G A, Lukashik N K, Ostrovskiĭ Iu M
Probl Endokrinol (Mosk). 1989 Jul-Aug;35(4):64-8.
Single administration of oxythiamine (200 mg/kg) or an isomolar amount of oxythiamineamyldisulfide to rats does not change the content of insulin in 72 h, whereas oxythiaminehexyldisulfide slightly increases the blood level of the hormone. Oxythiamine and its disulfides cause changes of the thyroid indicating considerable suppression of its function. It is assumed that hormonal mediation of oxythiamine nonspecific metabolic effects results predominantly from the involvement of the thyroid hormones rather than insulin.
给大鼠单次注射硫胺素（200毫克/千克）或等摩尔量的硫胺素戊二硫化物，72小时内胰岛素含量无变化，而硫胺素己二硫化物会使该激素的血液水平略有升高。硫胺素及其二硫化物会引起甲状腺变化，表明其功能受到显著抑制。据推测，硫胺素非特异性代谢作用的激素介导主要是由于甲状腺激素而非胰岛素的参与。
