Ostrovskiĭ Iu M, Zimatkina T I, Oparin D A
Vopr Med Khim. 1985 Sep-Oct;31(5):119-21.
Activity of transketolase was distinctly inhibited in mice brain after simultaneous administration of hydroxythiamine and 3,3-dimethyl-l-phenyl-l-phthalyl acetic acid. The rate of the enzyme inhibition correlated with an increase of the acid concentration in the mixture studied. The data obtained suggest that permeability of blood-brain barrier for hydroxythiamine was altered in simultaneous administration of the vitamin with some biologically active preparations.
同时给予小鼠脑硫胺素和3,3-二甲基-1-苯基-1-邻苯二甲酰基乙酸后，转酮醇酶的活性明显受到抑制。酶抑制率与所研究混合物中酸浓度的增加相关。所获得的数据表明，在将硫胺素与某些生物活性制剂同时给药时，血脑屏障对硫胺素的通透性发生了改变。
