支架的结构特性：干细胞分化的关键参数。
Structural properties of scaffolds: Crucial parameters towards stem cells differentiation.
作者信息
Ghasemi-Mobarakeh Laleh, Prabhakaran Molamma P, Tian Lingling, Shamirzaei-Jeshvaghani Elham, Dehghani Leila, Ramakrishna Seeram
机构信息
Laleh Ghasemi-Mobarakeh, Elham Shamirzaei-Jeshvaghani, Department of Textile Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Irans.
出版信息
World J Stem Cells. 2015 May 26;7(4):728-44. doi: 10.4252/wjsc.v7.i4.728.
Abstract
Tissue engineering is a multidisciplinary field that applies the principles of engineering and life-sciences for regeneration of damaged tissues. Stem cells have attracted much interest in tissue engineering as a cell source due to their ability to proliferate in an undifferentiated state for prolonged time and capability of differentiating to different cell types after induction. Scaffolds play an important role in tissue engineering as a substrate that can mimic the native extracellular matrix and the properties of scaffolds have been shown to affect the cell behavior such as the cell attachment, proliferation and differentiation. Here, we focus on the recent reports that investigated the various aspects of scaffolds including the materials used for scaffold fabrication, surface modification of scaffolds, topography and mechanical properties of scaffolds towards stem cells differentiation effect. We will present a more detailed overview on the effect of mechanical properties of scaffolds on stem cells fate.
摘要
组织工程是一个多学科领域，它应用工程学和生命科学原理来再生受损组织。干细胞因其能够在未分化状态下长时间增殖并在诱导后分化为不同细胞类型的能力，作为一种细胞来源在组织工程中引起了广泛关注。支架在组织工程中起着重要作用，作为一种能够模拟天然细胞外基质的底物，并且已表明支架的特性会影响细胞行为，如细胞附着、增殖和分化。在此，我们重点关注最近的一些报告，这些报告研究了支架的各个方面，包括用于支架制造的材料、支架的表面修饰、支架的拓扑结构和力学性能对干细胞分化的影响。我们将更详细地概述支架力学性能对干细胞命运的影响。
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