Shiozawa Yusuke, Eber Matthew R, Berry Janice E, Taichman Russell S
Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine , Winston-Salem, NC, USA ; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry , Ann Arbor, MI, USA.
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry , Ann Arbor, MI, USA.
Bonekey Rep. 2015 May 20;4:689. doi: 10.1038/bonekey.2015.57. eCollection 2015.
Bone marrow is a heterogeneous organ containing diverse cell types, and it is a preferred metastatic site for several solid tumors such as breast and prostate cancer. Recently, it has been shown that bone metastatic cancer cells interact with the bone marrow microenvironment to survive and grow, and thus this microenvironment is referred to as the 'metastatic niche'. Once cancer cells spread to distant organs such as bone, the prognosis for the patient is generally poor. There is an urgent need to establish a greater understanding of the mechanisms whereby the bone marrow niche influences bone metastasis. Here we discuss insights into the contribution of the bone marrow 'metastatic niche' to progression of bone metastatic disease, with a particular focus on cells of hematopoietic and mesenchymal origin.
骨髓是一种包含多种细胞类型的异质性器官，并且是乳腺癌和前列腺癌等多种实体瘤优先转移的部位。最近的研究表明，骨转移癌细胞与骨髓微环境相互作用以实现存活和生长，因此这种微环境被称为“转移龛”。一旦癌细胞扩散到诸如骨骼等远处器官，患者的预后通常较差。迫切需要更深入地了解骨髓龛影响骨转移的机制。在此，我们讨论关于骨髓“转移龛”对骨转移性疾病进展的作用的见解，特别关注造血和间充质来源的细胞。
