Li Xinyu, Fan Qing, Peng Xueqiang, Yang Shuo, Wei Shibo, Liu Jingang, Yang Liang, Li Hangyu
Department of General Surgery, The Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China.
Cell Death Discov. 2022 Jul 22;8(1):333. doi: 10.1038/s41420-022-01107-0.
Mesenchymal/stromal stem cells (MSCs) are a crucial component of the tumour microenvironment (TME). They can be recruited from normal tissues into the TME and educated by tumour cells to transform into tumour-associated MSCs, which are oncogenic cells that promote tumour development and progression by impacting or transforming into various kinds of cells, such as immune cells and endothelial cells. Targeting MSCs in the TME is a novel strategy to prevent malignant processes. Exosomes, as communicators, carry various RNAs and proteins and thus link MSCs and the TME, which provides options for improving outcomes and developing targeted treatment.
间充质/基质干细胞（MSCs）是肿瘤微环境（TME）的关键组成部分。它们可以从正常组织被招募到TME中，并被肿瘤细胞诱导转化为肿瘤相关MSCs，这些肿瘤相关MSCs是通过影响或转化为各种细胞（如免疫细胞和内皮细胞）来促进肿瘤发展和进展的致癌细胞。靶向TME中的MSCs是预防恶性进程的一种新策略。外泌体作为通讯者，携带各种RNA和蛋白质，从而连接MSCs和TME，这为改善治疗效果和开发靶向治疗提供了选择。
