Shao Yilei, Tao Aizhu, Jiang Hong, Mao Xinjie, Zhong Jianguang, Shen Meixiao, Lu Fan, Xu Zhe, Karp Carol L, Wang Jianhua
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States 2School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, China.
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, United States.
Invest Ophthalmol Vis Sci. 2015 Jun;56(6):3522-30. doi: 10.1167/iovs.15-16825.
We investigated the dynamic response of human accommodative elements as a function of age during accommodation using synchronized spectral domain optical coherence tomography devices (SD-OCT).
We enrolled 33 left eyes from 33 healthy subjects (age range, 20-39 years, 17 males and 16 females). Two SD-OCT devices were synchronized to simultaneously image the anterior segment through pupil and the ciliary muscle during 6.00 diopter (D) accommodation for approximately 3.7 seconds in two repeated measurements. The anterior segment parameters included the lens thickness (LT), radius of curvature of the lens anterior surface (LAC), maximum thickness of ciliary muscle (CMTMAX), and anterior length of the ciliary muscle (CMAL). A first-order exponential equation was used to fit the dynamic changes during accommodation. The age-related changes in the dynamic response and their relationship were calculated and compared.
The amplitude (r = -0.40 and 0.53 for LT and LAC, respectively) and peak velocity (r = -0.65 and 0.71 for LT and LAC, respectively) of the changes in LT and LAC significantly decreased with age (P < 0.05), whereas the parameters of the ciliary muscle remained unchanged (P > 0.05), except for the peak velocity of the CMAL (r = 0.44, P = 0.01). The difference in the time constant between the lens reshaping (LT and LAC) and CMTMAX increased with age (r = 0.46 and 0.57 for LT and LAC, respectively, P < 0.01). The changes in LT and LAC per millimeter of CMTMAX change decreased with age (r = -0.52 and -0.34, respectively, P < 0.05). The ciliary muscle forward movement correlated with the lens deformation (r = -0.35 and 0.40 for amplitude, while r = 0.36 and 0.58 for time constant, respectively, P < 0.05).
Age-related changes in the lens reshaping and ciliary muscle forward movement were found. Lens reshaping was much slower than the contraction of the ciliary muscle, especially in aging eyes, and this process required the ciliary muscle to contract more to reach a given response.
我们使用同步光谱域光学相干断层扫描设备（SD-OCT）研究人眼调节元件在调节过程中随年龄变化的动态反应。
我们招募了33名健康受试者（年龄范围20 - 39岁，17名男性和16名女性）的33只左眼。两台SD-OCT设备同步，在6.00屈光度（D）调节过程中，通过瞳孔和睫状肌同时对眼前节进行成像，持续约3.7秒，共进行两次重复测量。眼前节参数包括晶状体厚度（LT）、晶状体前表面曲率半径（LAC）、睫状肌最大厚度（CMTMAX）和睫状肌前长度（CMAL）。使用一阶指数方程拟合调节过程中的动态变化。计算并比较动态反应中与年龄相关的变化及其关系。
LT和LAC变化的幅度（LT和LAC的r分别为 -0.40和0.53）以及峰值速度（LT和LAC的r分别为 -0.65和0.71）随年龄显著降低（P < 0.05），而睫状肌参数除CMAL的峰值速度外保持不变（P > 0.05）（CMAL的r = 0.44，P = 0.01）。晶状体重塑（LT和LAC）与CMTMAX之间的时间常数差异随年龄增加（LT和LAC的r分别为0.46和0.57，P < 0.01）。每毫米CMTMAX变化时LT和LAC的变化随年龄降低（r分别为 -0.52和 -0.34，P < 0.05）。睫状肌向前运动与晶状体变形相关（幅度的r分别为 -0.35和0.40，时间常数的r分别为0.36和0.58，P < 0.05）。
发现晶状体重塑和睫状肌向前运动存在与年龄相关的变化。晶状体重塑比睫状肌收缩慢得多，尤其是在老年眼中，并且这个过程需要睫状肌更多地收缩以达到给定反应。
