The Relationship Between Age and the Morphology of the Crystalline Lens, Ciliary Muscle, Trabecular Meshwork, and Schlemm's Canal: An Swept-Source Optical Coherence Tomography Study.

To evaluate the effects of age on the morphologies of the crystalline lens, ciliary muscle (CM), Schlemm's canal (SC), and trabecular meshwork (TM) using swept-source optical coherence tomography (SS-OCT). Images of the crystalline lens and iridocorneal angle were obtained in healthy participants' eyes using SS-OCT. Morphological parameters of the crystalline lens, CM, and TM/SC were measured, and the relationship between these parameters and age was evaluated. A total of 62 healthy participants were enrolled, with an age range of 7-79 years. With adjustments for the effects of axial length and sex, both the nasal and temporal SC cross-sectional areas (CSA) and the cross-sectional area of the CM (CMA), distance from the scleral spur to the inner apex of the ciliary muscle (IA-SS), and nasal SC volume were negatively correlated with age ( ≤ 0.041). Meanwhile, the lens thickness (LT) ( < 0.001) and lens vault (LV) ( < 0.001) were positively correlated with age, and the radius of the curvature of the anterior lens (ALR) was negatively correlated with age ( < 0.001). Increasing age was associated with a thicker crystalline lens, a steeper anterior lens curvature, an anteriorly located and smaller CM, and a narrower SC. https://register.clinicaltrials.gov/prs/app/action/Select Protocol?sid=S000A3JZ&selectaction=Edit&uid=U00019K7&ts=4&cx=-c5xxp8, identifier [NCT04576884].