Tao Aizhu, Shao Yilei, Zhong Jianguang, Jiang Hong, Shen Meixiao, Wang Jianhua
Bascom Palmer Eye Institute, University of Miami, Miami, FL 33136, USA ; School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou, Zhejiang 325027, China.
Biomed Opt Express. 2013 Jun 4;4(7):1031-44. doi: 10.1364/BOE.4.001031. Print 2013 Jul 1.
We demonstrated the feasibility of a CMOS-based spectral domain OCT (SD-OCT) for versatile ophthalmic applications of imaging the corneal epithelium, limbus, ocular surface, contact lens, crystalline lens, retina, and full eye in vivo. The system was based on a single spectrometer and an alternating reference arm with four mirrors. A galvanometer scanner was used to switch the reference beam among the four mirrors, depending on the imaging application. An axial resolution of 7.7 μm in air, a scan depth of up to 37.7 mm in air, and a scan speed of up to 70,000 A-lines per second were achieved. The approach has the capability to provide high-resolution imaging of the corneal epithelium, contact lens, ocular surface, and tear meniscus. Using two reference mirrors, the zero delay lines were alternatively placed on the front cornea or on the back lens. The entire ocular anterior segment was imaged by registering and overlapping the two images. The full eye through the pupil was measured when the reference arm was switched among the four reference mirrors. After mounting a 60 D lens in the sample arm, this SD-OCT was used to image the retina, including the macula and optical nerve head. This system demonstrates versatility and simplicity for multi-purpose ophthalmic applications.
我们展示了基于互补金属氧化物半导体（CMOS）的光谱域光学相干断层扫描（SD - OCT）用于多种眼科应用的可行性，这些应用包括在体成像角膜上皮、角膜缘、眼表、隐形眼镜、晶状体、视网膜和全眼。该系统基于单个光谱仪和带有四个反射镜的交替参考臂。使用检流计扫描仪根据成像应用在四个反射镜之间切换参考光束。在空气中实现了7.7μm的轴向分辨率、高达37.7mm的扫描深度以及高达每秒70,000条A线的扫描速度。该方法能够提供角膜上皮、隐形眼镜、眼表和泪液弯月面的高分辨率成像。使用两个参考镜，零延迟线交替放置在前角膜或后晶状体上。通过配准和叠加这两个图像对整个眼前节进行成像。当参考臂在四个参考镜之间切换时，通过瞳孔对全眼进行测量。在样品臂中安装一个60D透镜后，该SD - OCT用于对包括黄斑和视神经乳头在内的视网膜进行成像。该系统展示了用于多用途眼科应用的多功能性和简易性。
