Erovic Ademovski S, Lingström P, Renvert S
Section for Health and Society, Kristianstad University, Kristianstad, Sweden.
Department of Cariology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Sweden.
Int J Dent Hyg. 2016 May;14(2):117-23. doi: 10.1111/idh.12148. Epub 2015 May 31.
To evaluate the effect of different mouth rinses 12 h after rinsing on genuine intra-oral halitosis.
Twenty-four adults with halitosis were included in a double-blind, crossover, randomized clinical trial. Halitosis was evaluated 12 h after rinsing with placebo and five mouth rinse products containing zinc acetate and chlorhexidine diacetate; zinc lactate, chlorhexidine and cetylpyridinium chloride; zinc acetate and chlorhexidine diacetate with reduced amounts of mint and menthol; zinc chloride and essential oil; and chlorine dioxide using the organoleptic method and a gas chromatograph. Test periods were separated by 1 week.
Hydrogen sulphide (H2 S), methyl mercaptan (MM) and the organoleptic scores (OLS) were significantly reduced 12 h following rinsing with all substances compared to placebo (P < 0.05). H2 S was more effectively reduced after rinsing with zinc acetate and chlorhexidine diacetate and zinc acetate and chlorhexidine diacetate with reduced amounts of mint and menthol compared to rinsing with zinc chloride and essential oil (P < 0.05), and significantly lower values of MM were obtained after rinsing with zinc acetate and chlorhexidine diacetate compared to zinc lactate, chlorhexidine and cetylpyridinium chloride (P < 0.05). The percentage effectively treated individuals (H2 S (<112 ppb), MM (<26 ppb) and OLS score <2) varied from 58% percentage (zinc acetate and chlorhexidine diacetate) to 26% (zinc chloride and essential oil).
All treatments resulted in reduction in halitosis 12 h after rinsing compared to placebo. H2 S and MM were most effectively reduced by zinc acetate and chlorhexidine diacetate.
评估不同漱口水在漱口12小时后对真性口腔口臭的影响。
24名有口臭的成年人被纳入一项双盲、交叉、随机临床试验。用安慰剂和五种含醋酸锌和二醋酸氯己定、乳酸锌、氯己定和十六烷基氯化吡啶、薄荷和薄荷醇含量降低的醋酸锌和二醋酸氯己定、氯化锌和精油、二氧化氯的漱口水产品漱口12小时后，采用感官方法和气相色谱法评估口臭情况。试验周期间隔为1周。
与安慰剂相比，用所有物质漱口12小时后，硫化氢（H₂S）、甲硫醇（MM）和感官评分（OLS）均显著降低（P < 0.05）。与用氯化锌和精油漱口相比，用醋酸锌和二醋酸氯己定以及薄荷和薄荷醇含量降低的醋酸锌和二醋酸氯己定漱口后，H₂S的降低效果更显著（P < 0.05），与用乳酸锌、氯己定和十六烷基氯化吡啶漱口相比，用醋酸锌和二醋酸氯己定漱口后MM的值显著更低（P < 0.05）。有效治疗个体的百分比（H₂S（<112 ppb）、MM（<26 ppb）和OLS评分<2）从58%（醋酸锌和二醋酸氯己定）到26%（氯化锌和精油）不等。
与安慰剂相比，所有治疗方法在漱口12小时后均能减轻口臭。醋酸锌和二醋酸氯己定对H₂S和MM的减轻效果最显著。
