Chapes S K, Chitko C G, Thaler R C, Nelssen J L, Anderson G A, Blecha F
Division of Biology, Kansas State University, Manhattan 66506.
Vet Immunol Immunopathol. 1989 Aug;22(1):91-9. doi: 10.1016/0165-2427(89)90166-9.
We report that 75% of conventionally housed 3- to 4-week-old swine already have detectable activated alveolar macrophages as measured by cytotoxicity of tumor cells. These macrophages can not be further activated by the biological response modifier N-acetylmuramyl-L-alanyl-Disoglutamine-2H2O (MDP). These macrophages lose cytotoxic activity when cultured for 24 h and this loss of activity can not be reversed by MDP. We suggest that MDP biological response modifier therapy of swine alveolar macrophages may not be a useful technique in preventing respiratory disease in swine.
我们报告称，通过肿瘤细胞毒性检测发现，常规饲养的3至4周龄猪中有75%已具有可检测到的活化肺泡巨噬细胞。这些巨噬细胞不能被生物反应调节剂N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺-2H2O（MDP）进一步激活。这些巨噬细胞在培养24小时后会失去细胞毒性活性，且MDP无法逆转这种活性丧失。我们认为，MDP对猪肺泡巨噬细胞的生物反应调节剂疗法可能不是预防猪呼吸道疾病的有效技术。
