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创伤后应激障碍对大麻戒断成功的影响。

The impact of posttraumatic stress disorder on cannabis quit success.

作者信息

Bonn-Miller Marcel O, Moos Rudolf H, Boden Matthew Tyler, Long W Robert, Kimerling Rachel, Trafton Jodie A

机构信息

National Center for PTSD, VA Palo Alto Health Care System , CA , USA .

出版信息

Am J Drug Alcohol Abuse. 2015;41(4):339-44. doi: 10.3109/00952990.2015.1043209. Epub 2015 Jun 4.

Abstract

BACKGROUND

Though a growing number of US Veterans are being diagnosed with cannabis use disorders, with posttraumatic stress disorder (PTSD) observed as the most frequently co-occurring psychiatric disorder among this population, no research has investigated the impact of PTSD diagnosis on cannabis quit success.

OBJECTIVES

The present study sought to determine the impact of PTSD on cannabis use following a self-guided quit attempt.

METHODS

Participants included 104, primarily male, cannabis-dependent US Veterans (Mage = 50.90 years, SDage = 9.90). The study design was prospective and included an assessment immediately prior to the quit attempt, and assessments weekly for the first 4 weeks post-quit, and then monthly through 6 months post-quit.

RESULTS

Results indicated that PTSD diagnosis was not associated with time to first lapse or relapse. However, individuals with PTSD used more cannabis at baseline and evidenced a slower initial decline in cannabis use immediately following the quit attempt. All findings were significant after accounting for alcohol and tobacco use across the cessation period, as well as co-occurring mood and anxiety disorder diagnoses.

CONCLUSION

Findings highlight the potential utility of interventions for individuals with cannabis use disorder and co-occurring PTSD, particularly early in a cessation attempt.

摘要

背景

尽管越来越多的美国退伍军人被诊断出患有大麻使用障碍,且创伤后应激障碍(PTSD)是该人群中最常同时出现的精神障碍,但尚无研究调查PTSD诊断对大麻戒断成功的影响。

目的

本研究旨在确定在自我引导的戒烟尝试后,PTSD对大麻使用的影响。

方法

参与者包括104名主要为男性的大麻依赖美国退伍军人(年龄中位数=50.90岁,标准差=9.90)。研究设计为前瞻性,包括在戒烟尝试前立即进行评估,在戒烟后的前4周每周进行评估,然后在戒烟后的6个月内每月进行评估。

结果

结果表明,PTSD诊断与首次复吸或复发的时间无关。然而,患有PTSD的个体在基线时使用的大麻更多,并且在戒烟尝试后立即出现大麻使用量最初下降较慢的情况。在考虑了整个戒烟期间的酒精和烟草使用以及同时出现的情绪和焦虑障碍诊断后,所有结果均具有显著性。

结论

研究结果突出了针对患有大麻使用障碍和并发PTSD的个体进行干预的潜在效用,尤其是在戒烟尝试的早期阶段。

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