Varela Juan Carlos, Tomlinson Stephen
Division of Hematology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Department of Microbiology and Immunology, Ralph H. Johnson Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC, USA.
Hematol Oncol Clin North Am. 2015 Jun;29(3):409-27. doi: 10.1016/j.hoc.2015.02.001. Epub 2015 Apr 4.
The complement system is an essential component of the immune system. It is a highly integrative system and has a number of functions, including host defense, removal of injured cells and debris, modulation of metabolic and regenerative processes, and regulation of adaptive immunity. Complement is activated via different pathways and it is regulated tightly by several mechanisms to prevent host injury. Imbalance between complement activation and regulation can manifest in disease and injury to self. This article provides an outline of complement activation pathways, regulatory mechanisms, and normal physiologic functions of the system.
补体系统是免疫系统的重要组成部分。它是一个高度整合的系统，具有多种功能，包括宿主防御、清除受损细胞和碎片、调节代谢和再生过程以及调节适应性免疫。补体通过不同途径激活，并受到多种机制的严格调控以防止宿主损伤。补体激活与调节之间的失衡可表现为疾病和自身损伤。本文概述了补体激活途径、调节机制以及该系统的正常生理功能。
