Lee Daegeun, Kim Tae-Hee, Lee Hae-Hyeog, Kim Jun-Mo, Jeon Dong-Su, Kim Yeon-Suk
Department of Obstetrics and Gynecology, Soonchunhyang University, College of Medicine, Bucheon, Korea.
Department of Urology, Soonchunhyang University, College of Medicine, Bucheon, Korea.
J Menopausal Med. 2015 Apr;21(1):41-6. doi: 10.6118/jmm.2015.21.1.41. Epub 2015 Apr 27.
It has been known that there is a difference in anogenital distance (AGD) in the animals and newborn depending on the exposure of androgenic hormones. The anatomical changes occur in the female genitalia in women after menopause. This was pilot study to find out whether the menopause affects AGD.
We evaluated a total of 50 women targeted for premenopausal and postmenopausal group in each 25 people. AGD was defined as a length between the posterior commissure of labia and anal center. AGD was measured in lithotomy position using sterile paper ruler. In order to control bias of the height and weight, which could influence the AGD, anogenital index (AGI) is defined as the weight divided by the AGD value. We used a Mann-Whitney U test to analyze the relationship between AGD and menopause for statistical analysis.
AGD was significantly longer in premenopausal women compared to postmenopausal women (34.8 ± 6.4 vs. 30.3 ± 6.6, P = 0.019). AGI was significantly higher in premenopausal women than postmenopausal women (1.7 ± 0.4 vs. 1.3 ± 0.3, P ≤ 0.000).
The changes of AGD and AGI in postmenopausal women demonstrated to have potential to be used as on scale predicting the physical changes that may occur after menopause. This study could be used as the cornerstone of a large-scale studies in the future.
已知动物和新生儿的肛门生殖距离（AGD）会因雄激素暴露情况而有所不同。绝经后女性的外生殖器会出现解剖学变化。本研究旨在探究绝经是否会影响AGD。
我们共评估了50名女性，分为绝经前组和绝经后组，每组25人。AGD定义为阴唇后联合与肛门中心之间的长度。在膀胱截石位使用无菌纸尺测量AGD。为控制可能影响AGD的身高和体重偏差，将肛门生殖指数（AGI）定义为体重除以AGD值。我们使用曼-惠特尼U检验分析AGD与绝经之间的关系以进行统计分析。
绝经前女性的AGD显著长于绝经后女性（34.8±6.4 vs. 30.3±6.6，P = 0.019）。绝经前女性的AGI显著高于绝经后女性（1.7±0.4 vs. 1.3±0.3，P≤0.000）。
绝经后女性AGD和AGI的变化表明有可能用作预测绝经后可能发生的身体变化的一个指标。本研究可作为未来大规模研究的基石。
