蛋白激酶C通过磷酸化葡萄糖转运蛋白1来增强细胞代谢。
PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1.
作者信息
Siska Peter J, Rathmell Jeffrey C
机构信息
Department of Pharmacology and Cancer Biology, Department of Immunology, Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA.
Department of Pharmacology and Cancer Biology, Department of Immunology, Duke Molecular Physiology Institute, Duke University, Durham, NC 27710, USA.
出版信息
Mol Cell. 2015 Jun 4;58(5):711-2. doi: 10.1016/j.molcel.2015.05.025.
Abstract
In this issue, Lee et al. (2015) show that PKC directly phosphorylates the glucose transporter Glut1, in order to promote glucose uptake in response to growth factor signaling.
摘要
在本期杂志中，Lee等人（2015年）表明，蛋白激酶C（PKC）直接使葡萄糖转运蛋白Glut1磷酸化，以便在生长因子信号传导响应中促进葡萄糖摄取。
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2
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3
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4
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6
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7
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8
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Mol Biol Cell. 2007 Apr;18(4):1437-46. doi: 10.1091/mbc.e06-07-0593. Epub 2007 Feb 14.
9
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Mol Biol Cell. 2005 Sep;16(9):4183-201. doi: 10.1091/mbc.e04-11-0978. Epub 2005 Jun 22.
10
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