Paavonen J, Miettinen A, Heinonen P K, Aaran R K, Teisala K, Aine R, Punnonen R, Laine S, Kallioniemi O P, Lehtinen M
Department of Obstetrics and Gynaecology, University of Helsinki, Finland.
Br J Obstet Gynaecol. 1989 May;96(5):574-9. doi: 10.1111/j.1471-0528.1989.tb03259.x.
Serum levels of CA 125 and other selected tumour markers were measured in 31 patients with proven pelvic inflammatory disease (PID). Ten (32%) of the patients had elevated CA 125, one (4%) had elevated CEA, and none had elevated CA 15-3, AFP or beta 2-microglobulin. Compared to patients with normal CA 125, patients with elevated CA 125 were older, more often users of intrauterine contraceptive devices, had longer duration of symptoms, higher erythrocyte sedimentation rates, and more often had an adnexal mass on pelvic examination. There was a correlation between CA 125 levels and the severity of adnexal inflammation as defined by laparoscopy. Isolation of specific micro-organisms from the upper genital tract was not associated with elevated CA 125. In most women serum levels of CA 125 decreased during treatment. PID should be considered as a major cause of positive CA 125 findings among young women.
对31例确诊为盆腔炎（PID）的患者测定了血清CA 125及其他选定肿瘤标志物的水平。10例（32%）患者CA 125升高，1例（4%）患者CEA升高，CA 15-3、AFP或β2-微球蛋白均无升高。与CA 125正常的患者相比，CA 125升高的患者年龄更大，更常使用宫内节育器，症状持续时间更长，红细胞沉降率更高，盆腔检查时附件包块更常见。CA 125水平与腹腔镜检查所定义的附件炎症严重程度之间存在相关性。从上生殖道分离出特定微生物与CA 125升高无关。在大多数女性中，治疗期间CA 125血清水平下降。PID应被视为年轻女性CA 125检测结果阳性的主要原因。
