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炎症指标与CA 125用于早期卵巢癌诊断的比较：来自意大利多中心前瞻性队列的证据

Inflammatory Indices vs. CA 125 for the Diagnosis of Early Ovarian Cancer: Evidence from a Multicenter Prospective Italian Cohort.

作者信息

Ronsini Carlo, Restaino Stefano, Ludovisi Manuela, Vizzielli Giuseppe, Di Donna Mariano Catello, Cucinella Giuseppe, Solazzo Maria Cristina, Scaffa Cono, De Franciscis Pasquale, Fordellone Mario, Cianci Stefano, Chiantera Vito

机构信息

Unit of Gynecologic Oncology, National Cancer Institute, IRCCS, Fondazione "G. Pascale", 80131 Naples, Italy.

Unit of Obstetrics and Gynecology, "Santa Maria della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy.

出版信息

J Pers Med. 2025 Sep 4;15(9):426. doi: 10.3390/jpm15090426.

DOI:10.3390/jpm15090426
PMID:41003129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12470830/
Abstract

Ovarian cancer (OC) remains one of the most challenging gynecologic malignancies to diagnose in its early stages, significantly impacting prognosis and treatment options [...].

摘要

卵巢癌（OC）仍然是最难在早期阶段诊断的妇科恶性肿瘤之一，对预后和治疗选择有重大影响[...]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c86/12470830/73a93a8be20b/jpm-15-00426-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c86/12470830/238b2464720a/jpm-15-00426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c86/12470830/55a1ce015c61/jpm-15-00426-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c86/12470830/73a93a8be20b/jpm-15-00426-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c86/12470830/238b2464720a/jpm-15-00426-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c86/12470830/55a1ce015c61/jpm-15-00426-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c86/12470830/73a93a8be20b/jpm-15-00426-g003.jpg

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本文引用的文献

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The Diagnostic Role of the Platelet-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis.血小板与淋巴细胞比值在卵巢癌中的诊断作用：一项系统评价和荟萃分析
Int J Mol Sci. 2025 Feb 21;26(5):1841. doi: 10.3390/ijms26051841.
2
Deep Myometrial Infiltration leads to a measurable Inflammatory Response in Endometrial Cancer. A Prospective Observational Study.肌层深层浸润导致子宫内膜癌出现可测量的炎症反应。一项前瞻性观察性研究。
Semin Oncol. 2024 Oct-Dec;51(5-6):149-153. doi: 10.1053/j.seminoncol.2024.10.002. Epub 2024 Oct 23.
3
SIR-EN-New Biomarker for Identifying Patients at Risk of Endometrial Carcinoma in Abnormal Uterine Bleeding at Menopause.
SIR-EN-用于识别绝经后异常子宫出血中子宫内膜癌风险患者的新型生物标志物。
Cancers (Basel). 2024 Oct 23;16(21):3567. doi: 10.3390/cancers16213567.
4
CA-125:CA72-4 ratio - towards a promising cost-effective tool in ovarian cancer diagnosis and monitoring of post-menopausal women under hormone treatment.CA-125:CA72-4 比值——一种有前途的、具有成本效益的卵巢癌诊断工具，可用于监测激素治疗的绝经后女性。
J Ovarian Res. 2024 Aug 10;17(1):164. doi: 10.1186/s13048-024-01487-0.
5
The Complex Tumor Microenvironment in Ovarian Cancer: Therapeutic Challenges and Opportunities.卵巢癌中的复杂肿瘤微环境：治疗挑战与机遇。
Curr Oncol. 2024 Jul 1;31(7):3826-3844. doi: 10.3390/curroncol31070283.
6
Mapping the tumor stress network reveals dynamic shifts in the stromal oxidative stress response.绘制肿瘤应激网络图谱揭示了基质氧化应激反应中的动态变化。
Cell Rep. 2024 May 28;43(5):114236. doi: 10.1016/j.celrep.2024.114236. Epub 2024 May 17.
7
Prognostic and clinicopathological significance of C-reactive protein in patients with ovarian cancer: a meta-analysis.C-反应蛋白在卵巢癌患者中的预后及临床病理意义：一项荟萃分析。
World J Surg Oncol. 2024 Jan 3;22(1):8. doi: 10.1186/s12957-023-03290-5.
8
Targeting the immune microenvironment for ovarian cancer therapy.针对卵巢癌治疗的免疫微环境。
Front Immunol. 2023 Dec 18;14:1328651. doi: 10.3389/fimmu.2023.1328651. eCollection 2023.
9
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Medicina (Kaunas). 2023 Sep 19;59(9):1684. doi: 10.3390/medicina59091684.
10
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