铜催化甲基与N-H键的直接酰胺化反应。
Copper catalysed direct amidation of methyl groups with N-H bonds.
作者信息
Huang Yao, Chen Tieqiao, Li Qiang, Zhou Yongbo, Yin Shuang-Feng
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
出版信息
Org Biomol Chem. 2015 Jul 14;13(26):7289-93. doi: 10.1039/c5ob00685f. Epub 2015 Jun 9.
An efficient copper catalyzed direct aerobic oxidative amidation of methyl groups of azaarylmethanes with N-H bonds producing amides is successfully developed, which can produce primary, secondary and tertiary amides, including those with functional groups. This reaction represents a straightforward method for the preparation of amides from the readily available hydrocarbon starting materials.
成功开发了一种高效的铜催化氮杂芳基甲烷甲基与N-H键的直接有氧氧化酰胺化反应，该反应能生成伯酰胺、仲酰胺和叔酰胺，包括带有官能团的酰胺。此反应是一种从易于获得的烃类起始原料制备酰胺的直接方法。
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