Bauman W A, Hashim A, Sershen H
Solomon A. Berson Research Laboratory, Veterans Administration MedicalCenter, Bronx, NY 10468.
Brain Res. 1989 Oct 23;500(1-2):156-60. doi: 10.1016/0006-8993(89)90309-0.
The concentrations of bioamines and their metabolites have been determined in March and April during arousal from hibernation in the cerebral cortex of the little brown bat (Myotis lucifugus). The patterns during arousal for dopamine and serotonin (5-HT) were similar with a significant fall in concentrations by 1 h of arousal, and an inverse relationship with their respective metabolites, 3,4-dihydroxyphenylacetic acid and 5-hydroxyindolacetic acid (5-HIAA). This suggests an acute release and metabolism of these bioamines with onset of arousal. During arousal, cerebral cortical concentrations of norepinephrine (NE) were not significantly changed. Levels of homovanillic acid were markedly depressed during hibernation and rose acutely with arousal. After arousal and 4 days of feeding in April, there was an increase in all bioamines and their metabolites studied except for NE. Of note is the marked decrease in the hibernating level of 5-HT and increase in its metabolite 5-HIAA from March to April, which may herald the natural termination of hibernation. Our results suggest that the brain of hibernators undergoes complex changes in the modulation of neurotransmitter systems which are consistent with both down- and up-regulation of neuronal activity in the maintenance of hibernation and the initiation of the arousal process.
在小棕蝠（Myotis lucifugus）从冬眠中苏醒的3月和4月期间，测定了其大脑皮层中生物胺及其代谢物的浓度。多巴胺和血清素（5-羟色胺，5-HT）在苏醒过程中的变化模式相似，在苏醒1小时后浓度显著下降，且与它们各自的代谢物3,4-二羟基苯乙酸和5-羟基吲哚乙酸（5-HIAA）呈负相关。这表明这些生物胺在苏醒开始时会急性释放并代谢。在苏醒过程中，大脑皮层去甲肾上腺素（NE）的浓度没有显著变化。高香草酸水平在冬眠期间显著降低，并随着苏醒而急剧上升。在4月苏醒并进食4天后，除NE外，所研究的所有生物胺及其代谢物的水平均有所增加。值得注意的是，从3月到4月，5-HT的冬眠水平显著下降，其代谢物5-HIAA增加，这可能预示着冬眠的自然结束。我们的结果表明，冬眠动物的大脑在神经递质系统调节方面经历了复杂的变化，这与维持冬眠和启动苏醒过程中神经元活动的下调和上调均相一致。
