Bauman W A
Solomon A. Berson Research Laboratory, Veterans Administration Medical Center, Bronx, New York 10468.
Pancreas. 1990 May;5(3):342-6. doi: 10.1097/00006676-199005000-00015.
Seasonal changes in pancreatic insulin and glucagon were investigated in the little brown bat (Myotis lucifugus). Pancreatic protein content increased 21% from the nonhibernating state in June compared to the nonhibernating or early hibernating state in late October, and then decreased 50% between October and the months of deep hibernation. The content of insulin and glucagon increased from June to October, and both hormones further increased during hibernation, when a fall in pancreatic protein content occurred. The concentration of both insulin and glucagon increased from October to February. Of note, the insulin concentration progressively increased during deep hibernation from February to April, whereas the glucagon concentration remained constantly elevated throughout this time interval. The persistent elevation of pancreatic glucagon during hibernation may be related to its role in counterregulation and carbohydrate homeostasis during fasting. The elevation of pancreatic insulin, and its further increase during hibernation, is less clear but may be hypothesized to provide a rapidly releasable storage pool required for immediate secretion during arousal, possibly to prevent a hyperosmolar state.
对棕蝠（小棕蝠）胰腺中胰岛素和胰高血糖素的季节性变化进行了研究。与10月末的非冬眠或早期冬眠状态相比，6月非冬眠状态下胰腺蛋白质含量增加了21%，然后在10月至深度冬眠月份期间下降了50%。胰岛素和胰高血糖素的含量从6月到10月增加，并且在冬眠期间这两种激素都进一步增加，此时胰腺蛋白质含量下降。胰岛素和胰高血糖素的浓度从10月到2月增加。值得注意的是，在2月至4月的深度冬眠期间，胰岛素浓度逐渐增加，而在此时间间隔内胰高血糖素浓度一直保持升高。冬眠期间胰腺胰高血糖素的持续升高可能与其在禁食期间的反调节和碳水化合物稳态中的作用有关。胰腺胰岛素的升高及其在冬眠期间的进一步增加尚不太清楚，但可以推测是为了提供一个快速可释放的储存库，以便在苏醒时立即分泌，可能是为了防止高渗状态。
