Pathak Jigna, Patel Shilpa, Iyer Janaki Subramanian, Mohanty Neeta
Department of Oral Pathology, MGM Dental College & Hospital, Navi Mumbai, Maharashtra, India.
Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India, Institute of Dental Sciences, Bhubaneswar, Odisha, India.
BMJ Case Rep. 2015 Jun 8;2015:bcr2014209038. doi: 10.1136/bcr-2014-209038.
Basaloid squamous cell carcinoma (BSCC) is a distinctive aggressive variant of squamous cell carcinoma. We present a case of a 60-year-old man with tender swelling in the right cheek region for 6 months and continuous unilateral nasal discharge for 2 months. Extraoral examination revealed an ovoid, well-defined swelling from the right infraorbital rim to the angle of the mouth superoinferiorly and the right lateral wall of the nose to preauricular region anteroposteriorly. Intraorally, an ulceroproliferative growth from right upper gingivobuccal sulcus to mid palatine raphe with bicortical expansion was evident. CT revealed a hypodense mass obliterating the right maxillary sinus. Histopathology showed closely packed basaloid cells, with hyperchromatic palisading nuclei, arranged in a solid pattern with a lobular configuration. Prominent areas of comedo necrosis and keratin pearl formation were seen. These features suggested BSCC. The patient underwent surgical excision with adjuvant radiation but was lost to follow-up after 6 months of radiation therapy.
基底样鳞状细胞癌（BSCC）是一种独特的侵袭性鳞状细胞癌变体。我们报告一例60岁男性患者，右侧脸颊区域出现疼痛性肿胀6个月，持续单侧鼻分泌物增多2个月。口外检查发现一个卵圆形、边界清晰的肿物，上至右下眼眶缘，下至口角，前至右侧鼻侧壁，后至耳前区域。口内可见一个从右上牙龈颊沟至腭中缝的溃疡增殖性肿物，并伴有双侧骨皮质膨胀。CT显示一个低密度肿物，占据了右侧上颌窦。组织病理学显示紧密排列的基底样细胞，核深染呈栅栏状，呈实性排列，有小叶状结构。可见明显的粉刺样坏死和角化珠形成区域。这些特征提示为基底样鳞状细胞癌。患者接受了手术切除并辅助放疗，但在放疗6个月后失访。
