Ii Rieko, Nakayama Masahiro, Tanaka Shuho, Akutsu Hiroyoshi, Tabuchi Keiji
Department of Otolaryngology - Head and Neck Surgery, University of Tsukuba, Tsukuba, JPN.
Department of Neurosurgery, Dokkyo Medical University, Mibu, JPN.
Cureus. 2023 Feb 22;15(2):e35293. doi: 10.7759/cureus.35293. eCollection 2023 Feb.
Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive subtype of squamous cell carcinoma (SCC). To date, no consensus on the treatment of BSCC has been established yet, especially in cases of invasion of the skull base. In addition, long-term prognosis has not been reported in T4b cases. Herein, we report the case of a 36-year-old Japanese man with locally advanced nasal BSCC that directly invaded the skull base and the brain. The patient was then treated with induction chemotherapy (IC). Owing to his good response to IC, we planned and performed en bloc resection followed by adjuvant proton beam therapy (PBT). Follow-up examinations five years after treatment showed no evidence of recurrence. This is the first report of IC followed by radical surgery and adjuvant PBT in a patient with T4b. IC has the potential to play an important role in treatment strategies.
基底样鳞状细胞癌（BSCC）是鳞状细胞癌（SCC）中一种罕见且侵袭性强的亚型。迄今为止，对于BSCC的治疗尚未达成共识，尤其是在颅底受侵的病例中。此外，T4b病例的长期预后尚未见报道。在此，我们报告一例36岁日本男性，患有局部晚期鼻腔BSCC，该肿瘤直接侵犯颅底和脑。患者随后接受了诱导化疗（IC）。由于其对IC反应良好，我们计划并实施了整块切除，随后进行辅助质子束治疗（PBT）。治疗后五年的随访检查未发现复发迹象。这是首例关于T4b患者接受IC后行根治性手术及辅助PBT的报道。IC在治疗策略中有可能发挥重要作用。
