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Synthesis of a thymosin beta 4-like peptide, deacetyl-thymosin beta Xen4, and its restorative effect on depressed lymphocyte blastogenic response to phytohemagglutinin (PHA) in uremic patients.

作者信息

Abiko T, Sekino H

出版信息

Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2467-71. doi: 10.1248/cpb.37.2467.

DOI:10.1248/cpb.37.2467
PMID:2605693
Abstract

An analog of thymosin beta Xen4 isolated from oocytes of Xenopus laevis, deacetyl-thymosin beta Xen4, was synthesized by assembling 6 peptide fragments, followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1:1) in trifluoroacetic acid in the presence of dimethylselenium. Finally, the deprotected peptide was incubated with dithiothreitol to reduce sulfoxide on the methionine side chain. The synthetic tritetracontapeptide was found to have a restoring effect on the impaired blastogenic response of T-lymphocytes isolated from uremic patients.

摘要

相似文献

1
Synthesis of a thymosin beta 4-like peptide, deacetyl-thymosin beta Xen4, and its restorative effect on depressed lymphocyte blastogenic response to phytohemagglutinin (PHA) in uremic patients.
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2
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Bioorg Med Chem. 1995 Oct;3(10):1369-75. doi: 10.1016/0968-0896(95)00121-v.

引用本文的文献

1
Relationship of amino acid sequence to immunological activity - syntheses and structure-activity relationships of thymosinβ 4 family.氨基酸序列与免疫活性的关系——胸腺肽β 4 家族的合成及构效关系。
Amino Acids. 1991 Jun;1(2):215-23. doi: 10.1007/BF00806919.
2
Distribution and biological activity ofβ-thymosins.β-胸腺素的分布与生物学活性。
Amino Acids. 1994 Feb;6(1):1-13. doi: 10.1007/BF00808118.
3
Synthesis of a new biological response modifier thyrnosin beta(4) analogue and its restorative effect on depressed.合成一种新的生物反应调节剂甲状腺素β（4）类似物及其对抑郁的修复作用。
Mediators Inflamm. 1992;1(2):113-9. doi: 10.1155/S096293519200019X.