• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

去乙酰胸腺素β12的合成及其对尿毒症患者受损T和B淋巴细胞免疫作用的研究

Synthesis of deacetyl-thymosin beta 12 and examination of its immunological effects on the impaired T and B lymphocytes in uremic patients.

作者信息

Abiko T, Sekino H

机构信息

Kidney Research Laboratory, Sendai, Japan.

出版信息

Biotechnol Ther. 1993;4(3-4):221-37.

PMID:8292971
Abstract

Deacetyl-thymosin beta 12 was synthesized in a conventional manner by assembling six peptide fragments followed by deprotection with 1 M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1:1) in trifluoroacetic acid in the presence of m-cresol and dimethyl-selenium. Incubation of peripheral lymphocytes isolated from uremic patients with the synthetic deacetyl-thymosin beta 12 showed an enhancing effect on the reduced beta lymphocytes but had no restoring effect on the impaired blastogenic response of T lymphocytes.

摘要

通过组装六个肽片段，然后在间甲酚和二甲基硒存在的情况下，于三氟乙酸中用1 M三氟甲磺酸 - 苯甲硫醚（摩尔比1:1）进行脱保护，以常规方式合成了去乙酰胸腺素β12。用合成的去乙酰胸腺素β12孵育从尿毒症患者分离的外周淋巴细胞，结果显示对减少的β淋巴细胞有增强作用，但对受损的T淋巴细胞增殖反应没有恢复作用。

相似文献

1
Synthesis of deacetyl-thymosin beta 12 and examination of its immunological effects on the impaired T and B lymphocytes in uremic patients.去乙酰胸腺素β12的合成及其对尿毒症患者受损T和B淋巴细胞免疫作用的研究
Biotechnol Ther. 1993;4(3-4):221-37.
2
Synthesis of deacetylthymosin beta 11 and its effect on the impaired T-lymphocytes of a uremic patient with common variable immunodeficiency.去乙酰胸腺素β11的合成及其对一名患有常见变异型免疫缺陷的尿毒症患者受损T淋巴细胞的影响。
Biotechnol Appl Biochem. 1988 Dec;10(6):576-88.
3
Synthesis of a thymosin beta 4-like peptide, deacetyl-thymosin beta Xen4, and its restorative effect on depressed lymphocyte blastogenic response to phytohemagglutinin (PHA) in uremic patients.
Chem Pharm Bull (Tokyo). 1989 Sep;37(9):2467-71. doi: 10.1248/cpb.37.2467.
4
Synthesis of rat parathymosin alpha fragment 1-28 and examination of its inhibitory activity towards the restoring activity of thymosin alpha 1 on the impaired T-lymphocytes of uremic patients.大鼠胸腺素α片段1-28的合成及其对胸腺素α1恢复尿毒症患者受损T淋巴细胞活性的抑制活性研究。
Chem Pharm Bull (Tokyo). 1991 Oct;39(10):2647-52. doi: 10.1248/cpb.39.2647.
5
Synthesis of prothymosin alpha deduced from nucleotide sequence of the murine cDNA and its effect on the impaired T lymphocytes of uremic patients.从小鼠cDNA核苷酸序列推导的前胸腺素α的合成及其对尿毒症患者受损T淋巴细胞的作用。
Biotechnol Ther. 1993;4(3-4):213-20.
6
Synthesis of human splenin (hSP) and examination of its immunological effects on the impaired T- and B-lymphocytes in uremic patients.人脾素（hSP）的合成及其对尿毒症患者受损T淋巴细胞和B淋巴细胞免疫效应的研究
Chem Pharm Bull (Tokyo). 1990 Feb;38(2):487-91. doi: 10.1248/cpb.38.487.
7
Synthesis of [I-NaI3]] thymopoietin II and examination of its immunological effect on the uremic T-lymphocytes.[I-NaI3]胸腺生成素II的合成及其对尿毒症T淋巴细胞免疫效应的研究。
Mediators Inflamm. 2000;9(3-4):201-6. doi: 10.1080/09629350020002930.
8
The synthesis of peptides with potential thymic hormone activity: the synthesis of endo-Arg38a-deacetylthymosin beta 10.具有潜在胸腺激素活性的肽的合成：内源性精氨酸38a-脱乙酰胸腺素β10的合成。
Biotechnol Appl Biochem. 1987 Feb;9(1):20-30.
9
Synthesis of deacetyl-thymosin beta 7 and examination of its immunological effect on the blastogenic response of T-lymphocytes of a uremic patient with cell-mediated immunodeficiency.去乙酰胸腺素β7的合成及其对一名患有细胞介导免疫缺陷的尿毒症患者T淋巴细胞增殖反应免疫效应的研究。
Chem Pharm Bull (Tokyo). 1988 Feb;36(2):700-7. doi: 10.1248/cpb.36.700.
10
Synthesis of [Phe(4F)3]thymopoietin II and examination of its immunological effect on the impaired blastogenic response of T-lymphocytes of uremic patients.
Bioorg Med Chem. 1995 Oct;3(10):1369-75. doi: 10.1016/0968-0896(95)00121-v.