[酗酒者血浆中异常神经节苷脂]

[Abnormal gangliosides in the plasma of alcoholics].

作者信息

Westphal S, Beyer K, Kielstein V, Schenk H

机构信息

Institut für Pathologische Biochemie, Medizinische Akademie, Magdeburg, G.D.R.

出版信息

Drug Alcohol Depend. 1989 Dec;24(3):251-3. doi: 10.1016/0376-8716(89)90063-x.

DOI:10.1016/0376-8716(89)90063-x

PMID:2606002

Abstract

Gangliosides were isolated from plasma of alcoholics. The pattern of gangliosides was compared with that of healthy humans. Up to seven fractions of gangliosides could be detected. In healthy subjects the following pattern was found: GM3 38.2%, SPG 6.0%, GD3 30.2%, GD1a 10.6%, GD1b 4.8%, GT1b 7.9%, GQ1b 2.2%. In alcoholics, significant differences were observed in the main ganglioside fractions GM3 (52.6%) and GD3 (17.5%).

摘要

从酗酒者的血浆中分离出神经节苷脂。将神经节苷脂的模式与健康人的进行比较。可检测到多达七个神经节苷脂组分。在健康受试者中发现以下模式：GM3 38.2%，SPG 6.0%，GD3 30.2%，GD1a 10.6%，GD1b 4.8%，GT1b 7.9%，GQ1b 2.2%。在酗酒者中，主要神经节苷脂组分GM3（52.6%）和GD3（17.5%）存在显著差异。