[酒精性患者红细胞膜及血浆中神经节苷脂成分的改变]

[Altered composition of gangliosides in the erythrocyte membrane and in the plasma of alcoholic patients].

作者信息

Westphal V S, Haselhorst U, Kielstein V, Schenk H

机构信息

Institut für Pathologische Biochemie, Medizinischen Akademie Magdeburg.

出版信息

Z Med Lab Diagn. 1990;31(7):371-4.

PMID:2092419

Abstract

Gangliosides were isolated from plasma and membranes of erythrocytes of alcoholics. The pattern of gangliosides were compared with the data of healthy donors. Up to 7 fractions of gangliosides could been detected after extraction, purification by column chromatography and fractionation by TLC. In alcoholics the main ganglioside fractions of plasma GM3 were increased (52.6%) and GD3 were decreased (17.5%). The GM3 and GD1b fraction of erythrocytes membranes were decreased significantly in alcoholics.

摘要

从酗酒者的血浆和红细胞膜中分离出神经节苷脂。将神经节苷脂的模式与健康供体的数据进行比较。通过柱色谱法提取、纯化并经薄层层析法分级后，可检测到多达7种神经节苷脂组分。在酗酒者中，血浆中主要神经节苷脂组分GM3增加了（52.6%），而GD3减少了（17.5%）。酗酒者红细胞膜中的GM3和GD1b组分显著减少。