[酒精中毒时异常的红细胞膜神经节苷脂]

[Abnormal erythrocyte membrane gangliosides in alcoholism].

作者信息

Haselhorst U, Beyer I, Schenk H, Kielstein V

机构信息

Institut für Pathologische Biochemie, Medizinische Akademie, Magdeburg, G.D.R.

出版信息

Drug Alcohol Depend. 1988 Feb;21(1):77-9. doi: 10.1016/0376-8716(88)90014-2.

DOI:10.1016/0376-8716(88)90014-2

PMID:3366058

Abstract

The pattern of gangliosides in membranes of erythrocytes was examined in healthy donors and in alcoholic subjects. Seven different gangliosides could be detected. In healthy donors the following pattern was found: GM3 = 17.6%, SPG = 43.1%, GD3 = 9.1%, GD1a = 12.8%, FucGD1b = 5.2%, GT1b = 6.7% and GX = 5.7%. The GM3 and FucDG1b fraction were decreased statistically significantly in alcoholics.

摘要

对健康献血者和酗酒者红细胞膜上神经节苷脂的模式进行了检测。可检测到七种不同的神经节苷脂。在健康献血者中发现了以下模式：GM3 = 17.6%，SPG = 43.1%，GD3 = 9.1%，GD1a = 12.8%，FucGD1b = 5.2%，GT1b = 6.7%，GX = 5.7%。在酗酒者中，GM3和FucDG1b部分在统计学上显著降低。