Oh Hyun, Hirano Jiro, Takai Hideki, Ogata Yorimasa
Department of Periodontology, Nihon University School of Dentistry.
J Oral Sci. 2015 Jun;57(2):67-71. doi: 10.2334/josnusd.57.67.
Inflammatory cytokines may have important roles in periodontitis. We assessed the effects of initial periodontal therapy on clinical periodontal parameters and interleukin-1β (IL-1β) level in gingival crevicular fluid (GCF) from chronic periodontitis (CP) patients. After initial screening, baseline periodontal parameters such as probing pocket depth (PPD) and bleeding on probing (BOP) were measured. GCF samples were collected from 13 shallow (≤3 mm) and deep (≥5 mm) PPD sites from 13 CP patients, and GCF volume and IL-1β concentration were determined at baseline (before scaling and root planning) and at 2 and 4 months after initial therapy. Baseline BOP rate, GCF volume, and IL-1β level were significantly higher at deep PPD sites than at shallow PPD sites. Significant improvements in PPD and BOP were observed at 2 and 4 months after periodontal initial therapy in deep PPD sites only. In contrast, GCF volume and IL-1β concentration were lower at 2 and 4 months after initial therapy at all sites. These results suggest that GCF volume and IL-1β level in samples reflect disease severity and that these variables are better than PPD and BOP as markers of gingival inflammation.
炎症细胞因子可能在牙周炎中发挥重要作用。我们评估了初始牙周治疗对慢性牙周炎（CP）患者临床牙周参数及龈沟液（GCF）中白细胞介素-1β（IL-1β）水平的影响。经过初步筛查后，测量了基线牙周参数，如探诊深度（PPD）和探诊出血（BOP）。从13例CP患者的13个浅（≤3 mm）和深（≥5 mm）PPD部位采集GCF样本，并在基线（龈上洁治和根面平整前）以及初始治疗后2个月和4个月测定GCF体积和IL-1β浓度。深PPD部位的基线BOP率、GCF体积和IL-1β水平显著高于浅PPD部位。仅在深PPD部位，牙周初始治疗后2个月和4个月时PPD和BOP有显著改善。相比之下，初始治疗后2个月和4个月时所有部位的GCF体积和IL-1β浓度均降低。这些结果表明，样本中的GCF体积和IL-1β水平反映了疾病严重程度，并且这些变量作为牙龈炎症标志物比PPD和BOP更好。
