Tanideh Nader, Ghafari Vajiheh, Ebrahimi Reyhaneh, Habibagahi Raha, Koohi-Hosseinabadi Omid, Iraji Aida
Stem Cells Technology Research Center and Dept. of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Students Research Committee, School of Dentistry, International Branch, Shiraz, University of Medical Sciences, Shiraz, Iran.
J Dent (Shiraz). 2020 Dec;21(4):314-321. doi: 10.30476/DENTJODS.2020.83660.1056.
Periodontitis is one of the most common bacterial infections of the oral cavity. It is important to find adjunctive methods for chemical treatment of periodontitis with less complications and proven therapeutic properties.
The aim of this study was to compare the effects of and on antioxidant, anti-inflammatory and histopathologic indices of induced periodontitis in male rats.
In this experimental animal study, forty adult male Sprague-Dawley rats were randomly divided into 4 groups (n=10) and then experimental periodontitis was induced by 3-0 nylon non-absorbable ligature. Each group was treated for 10 days as follows: 1) hydroalcoholic extract, 1000 mg/kg/daily, orally; 2) hydroalcoholic extract, 1000 mg/kg/daily, orally; 3) a mix of the two plants, 1000 mg/kg/ daily, orally, 4) normal saline solution. At the end of study, blood sample were obtained via cardiocentesis, the rats were euthanized, and their maxillae were removed. The samples were analyzed for histopathological scores and total antioxidant capacity and IL-1β were measured.
Mixed hydroalchoholic extract of and decreased IL-1β (4.3020±0.63), and increased the antioxidant parameter in comparison to the control group (3.1192±0.43) (< 0.001). There were significant histopathological differences between the treatment groups and the control group.
Mixed hydroalchoholic extract of and might be considered as an adjunctive treatment for periodontitis.
牙周炎是口腔最常见的细菌感染之一。找到用于牙周炎化学治疗且并发症更少、治疗特性已得到证实的辅助方法很重要。
本研究旨在比较[两种植物名称未给出]对雄性大鼠实验性牙周炎的抗氧化、抗炎和组织病理学指标的影响。
在本实验动物研究中，40只成年雄性Sprague-Dawley大鼠被随机分为4组（每组n = 10），然后用3-0尼龙不可吸收结扎线诱导实验性牙周炎。每组按以下方式治疗10天：1）[一种植物名称未给出]水醇提取物，1000毫克/千克/每日，口服；2）[另一种植物名称未给出]水醇提取物，1000毫克/千克/每日，口服；3）两种植物的混合物，1000毫克/千克/每日，口服；4）生理盐水溶液。研究结束时，通过心脏穿刺采集血样，对大鼠实施安乐死并取出上颌骨。对样本进行组织病理学评分分析，并测量总抗氧化能力和白细胞介素-1β。
与对照组（3.1192±0.43）相比，[两种植物名称未给出]的混合水醇提取物降低了白细胞介素-1β（4.3020±0.63），并提高了抗氧化参数（P<0.001）。治疗组与对照组之间存在显著的组织病理学差异。
[两种植物名称未给出]的混合水醇提取物可被视为牙周炎的辅助治疗方法。
