Dohanich G P, Barr P J, Witcher J A, Clemens L G
Physiol Behav. 1984 Jun;32(6):1021-6. doi: 10.1016/0031-9384(84)90296-8.
Forebrain infusion of cholinergic agonists activated the sexual response, lordosis, in ovariectomized female rats that had been primed with a low dose of estrogen. Carbachol, an agonist with both muscarinic and nicotinic properties, and oxotremorine, an agonist with a primarily muscarinic action, produced dose-related increases in the frequency of lordosis elicited by stimulus male rats. This facilitation of lordosis was prevented when females were pretreated systemically with atropine or scopolamine, two muscarinic receptor antagonists. These results indicate that the effect of carbachol and oxotremorine on lordosis is mediated by cholinergic muscarinic receptors. The location of these receptors within the brain has not been identified. Ventricular infusion of carbachol was as effective as infusion directly into the medial preoptic area (POA) and more effective than infusion directly into the ventromedial hypothalamus (VMH). Furthermore, when carbachol or oxotremorine was delivered to the POA through cannulae angled to avoid traversing the lateral ventricles, no facilitation of lordosis was observed. These data suggest that muscarinic receptors stimulated by central infusion of cholinergic agonists may not be located in either the POA or the VMH, two regions traditionally implicated in the regulation of lordosis.
向去卵巢的雌性大鼠前脑注入胆碱能激动剂，可激活其性反应——脊柱前凸，这些大鼠已用低剂量雌激素进行过预处理。卡巴胆碱是一种兼具毒蕈碱和烟碱特性的激动剂，毒扁豆碱是一种主要具有毒蕈碱作用的激动剂，它们均可使受刺激雄鼠引发的脊柱前凸频率呈剂量依赖性增加。当雌性大鼠全身预先用两种毒蕈碱受体拮抗剂阿托品或东莨菪碱处理后，这种脊柱前凸的促进作用就会被阻断。这些结果表明，卡巴胆碱和毒扁豆碱对脊柱前凸的作用是由胆碱能毒蕈碱受体介导的。这些受体在脑内的位置尚未确定。向脑室注入卡巴胆碱与直接注入内侧视前区（POA）的效果相同，且比直接注入腹内侧下丘脑（VMH）更有效。此外，当通过成角度的套管将卡巴胆碱或毒扁豆碱输送至POA以避免穿过侧脑室时，未观察到脊柱前凸的促进作用。这些数据表明，通过中枢注入胆碱能激动剂刺激的毒蕈碱受体可能不在POA或VMH中，这两个区域传统上被认为与脊柱前凸的调节有关。
