Mohanty M, Kumari T V, Rathinam K
Indian J Exp Biol. 1989 Mar;27(3):265-8.
Effect of infusion of stroma free haemoglobin solution into mice and rabbits was studied. Though no abnormalities were noted in mice, pulmonary vasospasm and hepatocytic necrosis were seen in all rabbits. In addition to reports that low adenosine deaminase levels in the solution could be a cause of vasoconstriction, it is proposed on the basis of present results that either denaturation of haemoglobin molecule itself or release of super oxide anion during oxygenation of haemoglobin, could cause cellular damage leading to toxicity.
研究了向小鼠和兔子输注无基质血红蛋白溶液的效果。虽然在小鼠中未观察到异常，但在所有兔子中均出现了肺血管痉挛和肝细胞坏死。除了有报道称溶液中腺苷脱氨酶水平低可能是血管收缩的原因外，根据目前的结果提出，血红蛋白分子本身的变性或血红蛋白氧合过程中超氧阴离子的释放，都可能导致细胞损伤并引发毒性。
