Ma Jianguo, Hu Weiguo, Zhang Ping, Sun Yujing, Wang Na, Teng Xiaoyan, Qiao Qian
1Department of Spine Surgery, PLA 425 Hospital , Sanya , China.
Cancer Invest. 2015;33(7):312-7. doi: 10.3109/07357907.2015.1044664. Epub 2015 Jun 12.
The relation between the polymorphisms of vascular endothelial growth factor (VEGF) and breast cancer remains inconclusive. In our meta-analysis based on 10,340 breast cancer patients and 10,388 controls, we found breast cancer susceptibility was elevated in individuals carrying the VEGF +936C allele, especially in Asians, and the +936CC increases tumor growth. The G allele of -634G/C polymorphism reduces breast cancer susceptibility in Asians, and breast cancer patients of -634GG genotype has decreased tumor growth. These results suggest that both the VEGF +936C/T and -634G/C polymorphisms influence breast cancer susceptibility and tumor growth, instead of metastasis.
血管内皮生长因子（VEGF）基因多态性与乳腺癌之间的关系尚无定论。在我们基于10340例乳腺癌患者和10388例对照的荟萃分析中，我们发现携带VEGF +936C等位基因的个体患乳腺癌的易感性升高，尤其是在亚洲人中，并且+936CC基因型会促进肿瘤生长。-634G/C多态性的G等位基因可降低亚洲人患乳腺癌的易感性，-634GG基因型的乳腺癌患者肿瘤生长减缓。这些结果表明，VEGF +936C/T和-634G/C多态性均影响乳腺癌易感性和肿瘤生长，而非转移。
