Internal Medicine Department, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
Immunol Invest. 2020 Feb;49(1-2):120-133. doi: 10.1080/08820139.2019.1659812. Epub 2019 Aug 28.
: The aim of this study was to assess the genetic association between vascular endothelial growth factor () gene polymorphisms and the risk of pre-eclampsia (PE).: A systematic literature search of several databases (PubMed, Embase, and the China National Knowledge Infrastructure (CNKI)) was conducted for case-control trials comparing polymorphisms (+936C/T, -634G/C, -2578C/A, and -1154G/A) with the risk of PE. Meta-analysis was performed using the Stata 12.0 software.: Twenty-three case-control studies on a total of 2597 PE patients and 3075 controls were included in our meta-analysis. The +936C/T polymorphism was observed to be associated with the risk of PE in the overall population (T vs. C: odds ratios (OR) = 1.434, 95% confidence interval (CI) = 1.120-1.836, = .004). However, the -634G/C, -2578C/A, and -1154G/A polymorphisms showed no association with the risk of PE. A subgroup analysis based on ethnicity found that the +936C/T polymorphism was associated with the risk of PE in both Europeans and Asians. Furthermore, the -634G/C polymorphism was found to be associated with the risk of PE in Europeans (C vs. G: OR = 1.428, 95% CI = 1.141-1.778, = .002). The polymorphisms at other loci were not associated with the risk of PE.: This meta-analysis suggests that +936C/T polymorphism, rather than -634G/C, -2578C/A, or -1154G/A polymorphisms, is associated with the risk of PE in the overall study population. However, the -634G/C polymorphism may be associated with the risk of developing PE in Europeans.
: 本研究旨在评估血管内皮生长因子（）基因多态性与先兆子痫（PE）风险之间的遗传关联。: 通过对多个数据库（PubMed、Embase 和中国国家知识基础设施（CNKI））进行系统文献检索，共纳入了 23 项比较+936C/T、-634G/C、-2578C/A 和-1154G/A 多态性与 PE 风险的病例对照研究。采用 Stata 12.0 软件进行荟萃分析。: 本荟萃分析共纳入了 2597 例 PE 患者和 3075 例对照的 23 项病例对照研究。总体人群中+936C/T 多态性与 PE 风险相关（T 对 C：比值比（OR）=1.434，95%置信区间（CI）=1.120-1.836，=0.004）。然而，-634G/C、-2578C/A 和-1154G/A 多态性与 PE 风险无关。基于种族的亚组分析发现，+936C/T 多态性与欧洲人和亚洲人 PE 风险相关。此外，-634G/C 多态性与欧洲人 PE 风险相关（C 对 G：OR=1.428，95%CI=1.141-1.778，=0.002）。其他部位的多态性与 PE 风险无关。: 本荟萃分析表明，+936C/T 多态性而不是-634G/C、-2578C/A 或-1154G/A 多态性与总体研究人群中 PE 的风险相关。然而，-634G/C 多态性可能与欧洲人 PE 风险相关。
