（18）氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）与转移性骨癌疼痛
(18)F-FDG PET/CT and pain in metastatic bone cancer.
作者信息
Struck Aaron F, Muzahir Saima, Hall Lance T
机构信息
Department of Neurology, University of Wisconsin Madison, WI 53705, USA ; Department of Radiology, Division of Nuclear Medicine, University of Wisconsin - Madison Madison, WI 53705, USA.
Department of Radiology, Division of Nuclear Medicine, University of Wisconsin - Madison Madison, WI 53705, USA.
出版信息
Am J Nucl Med Mol Imaging. 2015 Feb 15;5(3):287-92. eCollection 2015.
This study aims to determine if the pain intensity of patients with oncologic bone metastases (BM) correlates with metabolic activity measured by (18)F-FDG PET/CT. Twenty-eight patients, ages: 21-89 years (mean: 58.8) with BM were included in the study between September 2011 to September 2013. All patients completed a detailed questionnaire regarding pain symptoms on the visual analog scale (VAS), analgesic use, and areas of chronic pain, prior to obtaining an (18)F-FDG PET/CT. Pain symptoms were queried for 11 body regions including limbs, head, torso, etc. and the corresponding SUVmax of BMs within that region were modeled with the corresponding clinical data using a linear mixed effects model and a linear regression model. Overall 64 areas in the 28 subjects were found to have BM. SUVmax was found to be a significant predictor of pain intensity as measured by the VAS, with a P-value of 0.045, with a modest effect-size on linear regression of R(2) of 0.11.
本研究旨在确定肿瘤骨转移（BM）患者的疼痛强度是否与通过（18）F-FDG PET/CT测量的代谢活性相关。2011年9月至2013年9月期间，28例年龄在21 - 89岁（平均58.8岁）的BM患者被纳入研究。所有患者在进行（18）F-FDG PET/CT检查前，均完成了一份关于视觉模拟量表（VAS）上疼痛症状、镇痛药物使用及慢性疼痛区域的详细问卷。对包括四肢、头部、躯干等11个身体区域的疼痛症状进行了询问，并使用线性混合效应模型和线性回归模型将该区域内BM的相应最大标准摄取值（SUVmax）与相应临床数据进行建模。28名受试者中总共发现64个区域存在BM。发现SUVmax是VAS测量的疼痛强度的显著预测因子，P值为0.045，线性回归的效应量适度，决定系数R²为0.11。
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