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高Rab27A表达提示结直肠癌预后良好。

High Rab27A expression indicates favorable prognosis in CRC.

作者信息

Shi Chuanbing, Yang Xiaojun, Ni Yijiang, Hou Ning, Xu Li, Zhan Feng, Zhu Huijun, Xiong Lin, Chen Pingsheng

机构信息

Department of Pathology and Pathophysiology, School of Medicine, Southeast University, Nanjing, 210009, China.

Department of General Surgery, the Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210011, China.

出版信息

Diagn Pathol. 2015 Jun 13;10:68. doi: 10.1186/s13000-015-0303-3.

DOI:10.1186/s13000-015-0303-3
PMID:26070933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4465473/
Abstract

BACKGROUND

Rab27A is a peculiar member in Rab family and has been suggested to play essential roles in the development of human cancers. However, the association between Rab27A expression and clinicopathological characteristics of colorectal cancer (CRC) has not been elucidated yet.

METHODS

One-step quantitative real-time polymerase chain reaction (qPCR) test with 18 fresh-frozen CRC samples and immunohistochemistry (IHC) analysis in 112 CRC cases were executed to evaluate the relationship between Rab27A expression and the clinicopathological features of CRC. Cox regression and Kaplan-Meier survival analyses were performed to identify the prognostic factors for 112 CRC patients.

RESULTS

The results specified that the expression levels of Rab27A mRNA and protein were significantly higher in CRC tissues than that in matched non-cancerous tissues, in both qPCR test (p = 0.029) and IHC analysis (p = 0.020). The IHC data indicated that the Rab27A protein expression in CRC was statistically correlated with lymph node metastasis (p = 0.022) and TNM stage (p = 0.026). Cox multi-factor analysis and Kaplan-Meier method suggested Rab27A protein expression (p = 0.012) and tumor differentiation (p = 0.004) were significantly associated with the overall survival of CRC patients.

CONCLUSION

The data indicated the differentiate expression of Rab27A in CRC tissues and matched non-cancerous tissues. Rab27A may be used as a valuable prognostic biomarker for CRC patients.

摘要

背景

Rab27A是Rab家族中的一个特殊成员，已被认为在人类癌症发展中起重要作用。然而，Rab27A表达与结直肠癌（CRC）临床病理特征之间的关联尚未阐明。

方法

对18例新鲜冷冻的CRC样本进行一步定量实时聚合酶链反应（qPCR）检测，并对112例CRC病例进行免疫组织化学（IHC）分析，以评估Rab27A表达与CRC临床病理特征之间的关系。进行Cox回归和Kaplan-Meier生存分析，以确定112例CRC患者的预后因素。

结果

结果表明，在qPCR检测（p = 0.029）和IHC分析（p = 0.020）中，CRC组织中Rab27A mRNA和蛋白的表达水平均显著高于配对的癌旁组织。IHC数据表明，CRC中Rab27A蛋白表达与淋巴结转移（p = 0.022）和TNM分期（p = 0.026）具有统计学相关性。Cox多因素分析和Kaplan-Meier方法表明，Rab27A蛋白表达（p = 0.012）和肿瘤分化程度（p = 0.004）与CRC患者的总生存期显著相关。

结论

数据表明Rab27A在CRC组织和配对的癌旁组织中存在差异表达。Rab27A可能作为CRC患者有价值的预后生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd3/4465473/06b4025146c0/13000_2015_303_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd3/4465473/a9ef6c34450f/13000_2015_303_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd3/4465473/2a5d3ca00be1/13000_2015_303_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd3/4465473/06b4025146c0/13000_2015_303_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd3/4465473/a9ef6c34450f/13000_2015_303_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd3/4465473/2a5d3ca00be1/13000_2015_303_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6dd3/4465473/06b4025146c0/13000_2015_303_Fig3_HTML.jpg

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