人类HSP90AA1基因的调控与功能
Regulation and function of the human HSP90AA1 gene.
作者信息
Zuehlke Abbey D, Beebe Kristin, Neckers Len, Prince Thomas
机构信息
Urologic Oncologic Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
Urologic Oncologic Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
出版信息
Gene. 2015 Oct 1;570(1):8-16. doi: 10.1016/j.gene.2015.06.018. Epub 2015 Jun 10.
Abstract
Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different functions when compared to the constitutively expressed Hsp90β isoform, despite high amino acid sequence identity between the two proteins. These differences are likely due to variations in nucleotide sequence within non-coding regions, which allows for specific regulation through interaction with particular transcription factors, and to subtle changes in amino acid sequence that allow for unique post-translational modifications. This article will specifically focus on the expression, function and regulation of Hsp90α.
摘要
热休克蛋白90α（Hsp90α）由HSP90AA1基因编码，是分子伴侣Hsp90的应激诱导异构体。尽管这两种蛋白质的氨基酸序列高度同源，但与组成型表达的Hsp90β异构体相比，Hsp90α的调控方式不同且功能各异。这些差异可能是由于非编码区内核苷酸序列的变化，这种变化允许通过与特定转录因子的相互作用进行特异性调控，也可能是由于氨基酸序列的细微变化，从而允许进行独特的翻译后修饰。本文将特别关注Hsp90α的表达、功能和调控。
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