Chorostecki Jessica, Seraji-Bozorgzad Navid, Shah Aashka, Bao Fen, Bao Ginny, George Edwin, Gorden Veronica, Caon Christina, Frohman Elliot, Bhatti M Tariq, Khan Omar
Sastry Foundation Advanced Imaging Laboratory, Detroit, United States.
Movement Disorders Center, Department of Neurology, Wayne State University School of Medicine, Detroit, United States.
J Neurol Sci. 2015 Aug 15;355(1-2):44-8. doi: 10.1016/j.jns.2015.05.007. Epub 2015 May 12.
Parkinson's disease (PD) is a neurodegenerative disorder associated with dopaminergic cell loss and α-synuclein aggregation in Lewy bodies, which has been demonstrated in the retina.
We performed a spectral-domain optical coherence tomography (OCT) study in patients with PD and healthy controls to measure the peripapillary retinal nerve fiber layer thickness and macular volume. Intra-retinal segmentation was performed to measure the volume of the retinal nerve fiber (RNFL), ganglion cell (GCL), inner plexiform (IPL), inner nuclear (INL), outer plexiform (OPL), and outer nuclear (ONL) layers. Analysis was carried out blinded to the clinical status of study participants.
101 PD and 46 healthy control eyes were included in the study. In PD patients, peripapillary retinal nerve fiber layer was not significantly thinner (96.95 μm vs 94.42 μm, p=0.08) but macular volume was (8.58 mm3 vs 8.33 mm3, p=0.0002). Intra-retinal segmentation showed that PD subjects have reduced GCL, IPL, INL and ONL volumes. In contrast, the OPL volume was significantly increased (0.81 mm3 vs 0.78 mm3 p=0.0214).
Thickening of the OPL is a novel finding which may correspond to the localization of α-synuclein in the OPL of PD patients. We hypothesize that the enlargement of the OPL may represent a potential biomarker of α-synuclein aggregation in PD. This may have significant clinical implications.
帕金森病（PD）是一种神经退行性疾病，与多巴胺能细胞丢失和路易小体中的α-突触核蛋白聚集有关，这已在视网膜中得到证实。
我们对帕金森病患者和健康对照者进行了光谱域光学相干断层扫描（OCT）研究，以测量视乳头周围视网膜神经纤维层厚度和黄斑体积。进行视网膜内分割以测量视网膜神经纤维（RNFL）、神经节细胞（GCL）、内网状层（IPL）、内核层（INL）、外网状层（OPL）和外核层（ONL）的体积。分析是在对研究参与者的临床状况不知情的情况下进行的。
该研究纳入了101只帕金森病患者的眼睛和46只健康对照者的眼睛。在帕金森病患者中，视乳头周围视网膜神经纤维层没有明显变薄（96.95μm对94.42μm，p = 0.08），但黄斑体积变薄了（8.58mm³对8.33mm³，p = 0.0002）。视网膜内分割显示，帕金森病患者的GCL、IPL、INL和ONL体积减少。相比之下，OPL体积显著增加（0.81mm³对0.78mm³，p = 0.0214）。
OPL增厚是一个新发现，可能与帕金森病患者OPL中α-突触核蛋白的定位有关。我们假设OPL增大可能代表帕金森病中α-突触核蛋白聚集的潜在生物标志物。这可能具有重要的临床意义。
