Guo Xingli, Gao Lin, Wang Yu, Chiu David K Y, Wang Tong, Deng Yue
Brief Funct Genomics. 2016 Jan;15(1):38-46. doi: 10.1093/bfgp/elv022. Epub 2015 Jun 13.
Long noncoding RNAs (lncRNAs), generally longer than 200 nucleotides and with poor protein coding potential, are usually considered collectively as a heterogeneous class of RNAs. Recently, an increasing number of studies have shown that lncRNAs can involve in various critical biological processes and a number of complex human diseases. Not only the primary sequences of many lncRNAs are directly interrelated to a specific functional role, strong evidence suggests that their secondary structures are even more interrelated to their known functions. As functional molecules, lncRNAs have become more and more relevant to many researchers. Here, we review recent, state-of-the-art advances in the three levels (the primary sequence, the secondary structure and the function annotation) of the lncRNA research, as well as computational methods for lncRNA data analysis.
长链非编码RNA（lncRNA）通常长度超过200个核苷酸，且蛋白质编码潜力较差，通常被视为一类异质性的RNA。最近，越来越多的研究表明，lncRNA可参与各种关键的生物学过程以及许多复杂的人类疾病。不仅许多lncRNA的一级序列与特定的功能作用直接相关，有力的证据表明其二级结构与其已知功能的相关性更强。作为功能分子，lncRNA已越来越受到众多研究人员的关注。在此，我们综述lncRNA研究在三个层面（一级序列、二级结构和功能注释）的最新前沿进展，以及lncRNA数据分析的计算方法。
