中国宁波女性人乳头瘤病毒（HPV）感染的患病率及基因型分布

Prevalence and genotype distribution of HPV infection among women in Ningbo, China.

作者信息

Hong Hang, He Tian-feng, Ni Hong-xia, Zhang Shu, Xu Guo-zhang

机构信息

Ningbo Municipal Center for Disease Control and Prevention, Ningbo, China.

出版信息

Int J Gynaecol Obstet. 2015 Oct;131(1):96-9. doi: 10.1016/j.ijgo.2015.04.027. Epub 2015 Jun 3.

DOI:10.1016/j.ijgo.2015.04.027

PMID:26072045

Abstract

OBJECTIVE

To evaluate HPV prevalence and genotype distribution among women in Ningbo, China.

METHODS

A cluster-sampling study of women from four randomly selected villages was undertaken between April 1 and June 30, 2012. Married women who were not menstruating and had not had sexual intercourse, used vaginal medications, or performed vaginal douching within the previous 48hours were enrolled when attending community health centers for family planning appointments. Exfoliated cell specimens were collected for HPV DNA genotyping and cytologic diagnostic tests.

RESULTS

Among 1373 included women, 185 (13.5%) were found to be HPV positive and 178 (13.0%) had a high-risk HPV (HR-HPV) genotype. Among 56 women with cervical cytologic abnormalities, 35 (62.5%) had an HPV infection. The frequency of HPV or HR-HPV infections rose with increasing severity of cytological abnormalities (P<0.001 for both). HPV52 was the most prevalent genotype, followed by HPV58, HPV16, HPV33, and HPV68. An HPV prevalence peak was observed in women aged 40-49 years (101/564 [17.9%]).

CONCLUSION

In Ningbo, many women with cervical cytologic abnormalities have HPV infection. Vaccines targeting HPV52 and HPV58 in conjunction with HPV16 and HPV18 are required for the prevention and treatment of cervical lesions in Chinese women.

摘要

目的

评估中国宁波女性人乳头瘤病毒（HPV）的感染率及基因型分布情况。

方法

2012年4月1日至6月30日，对随机抽取的四个村庄的女性进行整群抽样研究。纳入在社区卫生中心进行计划生育检查的已婚女性，要求她们非经期，且在过去48小时内未发生性行为、未使用阴道药物或进行阴道灌洗。收集脱落细胞标本进行HPV DNA基因分型和细胞学诊断检测。

结果

在纳入研究的1373名女性中，185名（13.5%）HPV检测呈阳性，178名（13.0%）感染高危型HPV（HR-HPV）基因型。在56名宫颈细胞学异常的女性中，35名（62.5%）感染了HPV。HPV或HR-HPV感染率随细胞学异常严重程度的增加而上升（两者P均<0.001）。HPV52是最常见的基因型，其次是HPV58、HPV16、HPV33和HPV68。40-49岁女性中观察到HPV感染率高峰（101/564 [17.9%]）。