华东地区 65613 例女性人乳头瘤病毒感染的流行情况。
Prevalence of human papillomavirus infection of 65,613 women in East China.
机构信息
Laboratory of gene amplification, Kingmed Diagnostics, Nanjing, 210043, China.
Center of Clinical Laboratory Science, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Baiziting 42, Nanjing, 210009, China.
出版信息
BMC Public Health. 2019 Feb 11;19(1):178. doi: 10.1186/s12889-019-6487-9.
BACKGROUND
The infection with human papillomavirus (HPV) is the major cause of genital disease. This study assessed the prevalence and genotype of HPV among outpatient women and healthy women in Jiangsu, East China.
METHODS
A total of 65,613 women aged 16-85 years were recruited from Nanjing Kingmed Diagnostics, including 45,736 outpatients and 19,877 healthy women. The cervico-vaginal cells were collected and then HPV types were detected using the Tellgenplex™ HPV DNA Test.
RESULTS
The overall HPV prevalence was 17.7% for outpatients and 10.6% for healthy women. 13.7% outpatients were infected with a single HPV type and 4.0% were infected with multiple HPV types. Regarding healthy women, 8.5 and 2.1% were infected with single and multiple HPV types, respectively. The two most commonly detected HPV types were HPV 16 and 58 regardless of single- or multiple-type infection or source of the participants. HPV16 + 58 was the most commonly identified multiple genotype in outpatients, while HPV16 + 52 was frequently detected in healthy women. Highest prevalence rate was found in outpatients aged < 20 years and ≥ 60 years.
CONCLUSIONS
This study revealed the prevalence characteristics of HPV in both outpatient women and healthy women in Jiangsu province.
背景
人乳头瘤病毒（HPV）感染是导致生殖器疾病的主要原因。本研究评估了华东地区江苏地区门诊妇女和健康妇女 HPV 的流行率和基因型。
方法
本研究共招募了 65613 名年龄在 16-85 岁的女性，包括 45736 名门诊患者和 19877 名健康女性，采集宫颈阴道细胞，采用 Tellgenplex™ HPV DNA 检测试剂盒检测 HPV 型别。
结果
门诊患者 HPV 总感染率为 17.7%，健康女性为 10.6%。13.7%的门诊患者感染单一 HPV 型，4.0%的门诊患者感染多种 HPV 型。健康女性中，分别有 8.5%和 2.1%感染单一和多种 HPV 型。无论单一或多重感染或参与者来源，最常见的两种 HPV 型均为 HPV 16 和 58。HPV16+58 是门诊患者中最常见的多重基因型，而 HPV16+52 在健康女性中经常被检测到。年龄<20 岁和≥60 岁的门诊患者 HPV 感染率最高。
结论
本研究揭示了江苏省门诊妇女和健康妇女 HPV 的流行特征。
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