Chávez R, Sánchez S, Ulloa-Aguirre A, Domínguez R
Laboratory of Biology of Reproduction, Escuela Nacional de Estudios Profesionales Zaragoza, UNAM, Mexico D.F., Mexico.
J Endocrinol. 1989 Dec;123(3):441-4. doi: 10.1677/joe.0.1230441.
The effects of unilateral section of the right or left vagus nerve (SRVN, SLVN) performed on different days of the oestrous cycle of the rat were analysed. Vagal nerve section on the day of oestrus or on day 1 of dioestrus (D1) altered oestrous cyclicity in a more significant way than when it was performed on day 2 of dioestrus (D2) or pro-oestrus (6/58 maintained normal oestrous cycles compared with 32/39 that did not; P less than 0.01). Ovulation rate at oestrus was lower in rats with SLVN than in the sham-operated group (32/47 vs 28/32; P less than 0.05). The number of ova shed by the left ovary was reduced in sham-operated rats and in animals with SRVN and SLVN, whereas the number shed by the right ovary was not modified. The day of the oestrous cycle on which the vagus nerve was cut also influenced the number of ova shed. No changes in plasma levels of FSH at oestrus were observed in animals with SRVN or SLVN. The results indicate that vagal manipulations performed at the beginning of the oestrous cycle (day of oestrus and D1) induce more changes on oestrous cyclicity and ovulation than when they are performed during the second half of the cycle (D2 and pro-oestrus). In addition, the left ovary is more sensitive to neural manipulation than is the right one.
分析了在大鼠发情周期的不同日子进行右侧或左侧迷走神经单侧切断（SRVN，SLVN）的影响。在发情日或动情间期第1天（D1）切断迷走神经比在动情间期第2天（D2）或发情前期切断时对发情周期的影响更显著（6/58维持正常发情周期，而未维持正常周期的为32/39；P<0.01）。SLVN大鼠发情期的排卵率低于假手术组（32/47对28/32；P<0.05）。假手术大鼠以及接受SRVN和SLVN的动物，左侧卵巢排出的卵子数量减少，而右侧卵巢排出的卵子数量未改变。切断迷走神经的发情周期日也会影响排出的卵子数量。SRVN或SLVN动物在发情期时血浆FSH水平未观察到变化。结果表明，在发情周期开始时（发情日和D1）进行迷走神经操作比在周期后半期（D2和发情前期）进行时对发情周期和排卵的影响更大。此外，左侧卵巢比右侧卵巢对神经操作更敏感。
