抗肿瘤剂，110. 落地生根苷B，一种来自落地生根的新型强效细胞毒性蟾蜍二烯羟酸内酯。
Antitumor agents, 110. Bryophyllin B, a novel potent cytotoxic bufadienolide from Bryophyllum pinnatum.
作者信息
Yamagishi T, Haruna M, Yan X Z, Chang J J, Lee K H
机构信息
Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
出版信息
J Nat Prod. 1989 Sep-Oct;52(5):1071-9. doi: 10.1021/np50065a025.
PMID:2607348
Abstract
Bryophyllin B [1], a potent cytotoxic bufadienolide, has been isolated from Bryophyllum pinnatum and its structure confirmed by the use of 2D-nmr techniques and difference nOe method. Transformation of bryotoxin C [2] to 1 with acid is also discussed.
摘要
Bryophyllin B [1]是一种强效细胞毒性蟾蜍二烯羟酸内酯，已从落地生根中分离出来，其结构通过二维核磁共振技术和差示核Overhauser效应方法得以确认。文中还讨论了用酸将苔藓毒素C [2]转化为1的过程。
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