Joy Jordan M, Lowery Ryan P, Falcone Paul H, Vogel Roxanne M, Mosman Matt M, Tai Chih-Yin, Carson Laura R, Kimber Dylan, Choate David, Kim Michael P, Wilson Jacob M, Moon Jordan R
MusclePharm Sports Science Institute, MusclePharm Corp., Denver, CO, USA.
Health Science and Human Performance Department, University of Tampa, Tampa, FL, USA.
Food Nutr Res. 2015 Jun 16;59:27470. doi: 10.3402/fnr.v59.27470. eCollection 2015.
Pre-workout supplements (PWS) have become increasingly popular with recreational and competitive athletes. While many ingredients used in PWS have had their safety assessed, the interactions when combined are less understood.
The purpose of this study was to examine the safety of 1 and 2 servings of a PWS.
Forty-four males and females (24.4±4.6 years; 174.7±9.3 cm; 78.9±18.6 kg) from two laboratories participated in this study. Subjects were randomly assigned to consume either one serving (G1; n=14) or two servings (G2; n=18) of PWS or serve as an unsupplemented control (CRL; n=12). Blood draws for safety panels were conducted by a trained phlebotomist before and after the supplementation period.
Pooled data from both laboratories revealed significant group×time interactions (p<0.05) for mean corpuscular hemoglobin (MCH; CRL: 30.9±0.8-31.0±0.9 pg; G1: 30.7±1.1-30.2±0.7 pg; G2: 30.9±1.2-30.9±1.1 pg), MCH concentration (CRL: 34.0±0.9-34.4±0.7 g/dL; G1: 34.1±0.9-33.8±0.6 g/dL; G2: 34.0±1.0-33.8±0.8 g/dL), platelets (CRL: 261.9±45.7-255.2±41.2×10(3)/µL; G1: 223.8±47.7-238.7±49.6×10(3)/µL; G2: 239.1±28.3-230.8±34.5×10(3)/µL), serum glucose (CRL: 84.1±5.2-83.3±5.8 mg/dL; G1: 86.5±7.9-89.7±5.6 mg/dL; G2: 87.4±7.2-89.9±6.6 mg/dL), sodium (CRL: 137.0±2.7-136.4±2.4 mmol/L; 139.6±1.4-140.0±2.2 mmol/L; G2: 139.0±2.2-138.7±1.7 mmol/L), albumin (CRL: 4.4±0.15-4.4±0.22 g/dL; G1: 4.5±0.19-4.5±0.13 g/dL; G2: 4.6±0.28-4.3±0.13 g/dL), and albumin:globulin (CRL: 1.8±0.30-1.8±0.28; G1: 1.9±0.30-2.0±0.31; G2: 1.8±0.34-1.8±0.34). Each of these variables remained within the clinical reference ranges.
The PWS appears to be safe for heart, liver, and kidney function in both one-serving and two-serving doses when consumed daily for 28 days. Despite the changes observed for select variables, no variable reached clinical significance.
运动前补充剂（PWS）在休闲运动员和竞技运动员中越来越受欢迎。虽然PWS中使用的许多成分已进行过安全性评估，但对其组合时的相互作用了解较少。
本研究旨在检验一份和两份PWS的安全性。
来自两个实验室的44名男性和女性（24.4±4.6岁；身高174.7±9.3厘米；体重78.9±18.6千克）参与了本研究。受试者被随机分配，分别服用一份（G1组；n = 14）或两份（G2组；n = 18）PWS，或作为未补充的对照组（CRL组；n = 12）。在补充期前后，由训练有素的采血人员采集血液进行安全性指标检测。
两个实验室的汇总数据显示，平均红细胞血红蛋白含量（MCH；CRL组：30.9±0.8 - 31.0±0.9皮克；G1组：30.7±1.1 - 30.2±0.7皮克；G2组：30.9±1.2 - 30.9±1.1皮克）、MCH浓度（CRL组：34.0±0.9 - 34.4±0.7克/分升；G1组：34.1±0.9 - 33.8±0.6克/分升；G2组：34.0±1.0 - 33.8±0.8克/分升）、血小板（CRL组：261.9±45.7 - 255.2±41.2×10³/微升；G1组：223.8±47.7 - 238.7±49.6×10³/微升；G2组：239.1±28.3 - 230.8±34.5×10³/微升）、血清葡萄糖（CRL组：84.1±5.2 - 83.3±5.8毫克/分升；G1组：86.5±7.9 - 89.7±5.6毫克/分升；G2组：87.4±7.2 - 89.9±6.6毫克/分升）、钠（CRL组：137.0±2.7 - 136.4±2.4毫摩尔/升；G1组：139.6±1.4 - 140.0±2.2毫摩尔/升；G2组：139.0±2.2 - 138.7±1.7毫摩尔/升）、白蛋白（CRL组：4.4±0.15 - 4.4±0.22克/分升；G1组：4.5±0.19 - 4.5±0.13克/分升；G2组：4.6±0.28 - 4.3±0.13克/分升）以及白蛋白与球蛋白比值（CRL组：1.8±0.30 - 1.8±0.28；G1组：1.9±0.30 - 2.0±0.31；G2组：1.8±0.34 - 1.8±0.34）存在显著的组×时间交互作用（p<0.05）。这些变量中的每一个均保持在临床参考范围内。
每天服用28天，一份和两份剂量的PWS对心脏、肝脏和肾脏功能似乎都是安全的。尽管观察到某些变量有变化，但没有一个变量达到临床显著性。
