Neubert R, Hause C, Härtl A, Amlacher R
Sektion Pharmazie der Martin-Luther-Universität Halle, Jena.
Pharmazie. 1989 Sep;44(9):630-1.
Following i.v. administration of the hydrophilic drug bretylium (1) and the lipophilic hexylsalicylic acid (2) in rats the plasma levels of 2 were increased due to an increased intestinal reabsorption of 2. Under these conditions the biliary eliminated amount of 2 was 8 times higher than that following the administration of 2 alone. The eneteroheptic circulation of 2 was found to be interrupted following i.v. administration of 1 and 2 and additional oral administration of an anionic exchanger. Then the plasma levels of 2 were not influenced by 1. On other hand the plasma levels of 2 appear to be too low in order to influence those of 1.
在大鼠静脉注射亲水性药物溴苄铵（1）和亲脂性己基水杨酸（2）后，由于2的肠道重吸收增加，2的血浆水平升高。在这些条件下，2经胆汁消除的量比单独给予2时高8倍。静脉注射1和2并额外口服阴离子交换剂后，发现2的肠肝循环被中断。此时，2的血浆水平不受1的影响。另一方面，2的血浆水平似乎过低，无法影响1的血浆水平。
